PMID- 23957657
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20181202
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 35
IP  - 10
DP  - 2013
TI  - Interleukin-18, CRP and procalcitonin levels in vesicoureteral reflux and reflux 
      nephropathy.
PG  - 1319-22
LID - 10.3109/0886022X.2013.826137 [doi]
AB  - BACKGROUND: Some patients with vesicoureteral reflux (VUR) develop reflux 
      nephropathy (RN) and a number of them progress to chronic kidney disease (CKD). 
      However, it is unclear to predict which patient will develop RN and/or CKD. The 
      aim of this study is to evaluate the role of Interleukin-18 (IL-18), C-reactive 
      protein (CRP) and procalcitonin (PCT) as an indicator of RN in VUR. METHODS: 
      Ninety-three children aged 3.5-16 years with primary VUR were enrolled. Patients 
      were divided into two groups according to the presence of renal scarring (RS). 
      CRP, PCT, blood urea nitrogen (BUN), serum creatinine (Scr), urinary protein 
      (Up), creatinine (Ucr) and microalbumin (Umalb), serum and urine IL-18 levels 
      were determined during urinary tract infection (UTI) free episode. RESULTS: BUN, 
      Scr, Up/Ucr and Umalb/Ucr concentrations were higher whereas calculated 
      creatinine clearance (Ccr) values were lower in RS (+) group compared to RS (-) 
      group. CRP, PCT, serum and urine IL-18 levels and mean urine IL-18/Cr 
      concentrations were similar in both groups. Serum and urine IL-18 levels did not 
      differ according to the grade of VUR. No significant correlation was found 
      between CRP, PCT and IL-18. CONCLUSIONS: Proteinuria and microalbuminuria are 
      valuable hallmarks of RN. CRP and PCT seem not to be reliable indicators of RN in 
      VUR patients. Moreover, serum and urine IL-18 might not predict RN.
FAU - Yavuz, Sevgi
AU  - Yavuz S
AD  - Division of Pediatric Nephrology, Cukurova University Hospital , Adana , Turkey.
FAU - Anarat, Ali
AU  - Anarat A
FAU - Bayazit, Aysun Karabay
AU  - Bayazit AK
LA  - eng
PT  - Journal Article
DEP - 20130820
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (CALCA protein, human)
RN  - 0 (Interleukin-18)
RN  - 0 (Protein Precursors)
RN  - 9007-12-9 (Calcitonin)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
MH  - Adolescent
MH  - C-Reactive Protein/*metabolism
MH  - Calcitonin/*blood
MH  - Calcitonin Gene-Related Peptide
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Interleukin-18/*blood/urine
MH  - Kidney Diseases/*blood/etiology/urine
MH  - Male
MH  - Prospective Studies
MH  - Protein Precursors/*blood
MH  - Vesico-Ureteral Reflux/*blood/complications/urine
EDAT- 2013/08/21 06:00
MHDA- 2014/06/21 06:00
CRDT- 2013/08/21 06:00
PHST- 2013/08/21 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
AID - 10.3109/0886022X.2013.826137 [doi]
PST - ppublish
SO  - Ren Fail. 2013;35(10):1319-22. doi: 10.3109/0886022X.2013.826137. Epub 2013 Aug 
      20.