PMID- 23958244
OWN - NLM
STAT- MEDLINE
DCOM- 20140324
LR  - 20171116
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 230
IP  - 1
DP  - 2013 Sep
TI  - Persistent organic pollutants and hyperuricemia in the U.S. general population.
PG  - 1-5
LID - S0021-9150(13)00378-X [pii]
LID - 10.1016/j.atherosclerosis.2013.06.012 [doi]
AB  - BACKGROUND: Background exposure to persistent organic pollutants (POPs) has 
      emerged as a new risk factor for metabolic syndrome (MetS), while hyperuricemia 
      is associated with MetS through unclear mechanisms. OBJECTIVE: We examined 
      cross-sectional data for consistency with the hypothesis that POPs are a common 
      underlying risk factor of both MetS and hyperuricemia. METHODS: We evaluated 
      associations of POPs with hyperuricemia in subjects aged >/=20 years in the 
      population-based National Health and Nutrition Examination Survey (NHANES) 
      2003-2004. Sample size was n = 1331 for organochlorine (OC) pesticides and n = 
      1299 for polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans 
      (PCDFs), and polychlorinated biphenyls (PCBs). RESULTS: Among all subjects, the 
      risk of hyperuricemia was higher for higher serum concentrations of OC 
      pesticides, PCDDs, and dioxin-like PCBs. PCDFs and nondioxin-like PCBs did not 
      show any clear trend. Adjusted odds ratios (ORs) for OC pesticides, PCDDs, and 
      dioxin-like PCBs were 1.0, 2.4, 2.3, 3.0, and 2.5 (P trend = 0.05), 1.0, 1.6, 
      1.4, 2.1, and 2.5 (P trend = 0.01), and 1.0, 1.3, 1.4, 1.3, and 2.4 (P trend = 
      0.04). When we restricted the analyses to subjects without MetS, all these 
      associations appeared to strengthen. CONCLUSION: This study is consistent with 
      our hypothesis that the risk of hyperuricemia relates to background exposure to a 
      mixture of POPs even among persons without MetS. There should be further research 
      about whether avoiding exposure to POPs and otherwise decreasing body burden of 
      POPs would be helpful to prevent or manage hyperuricemia or gout.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Lee, Yu-Mi
AU  - Lee YM
AD  - Department of Preventative Medicine, School of Medicine, Kyungpook National 
      University, Jung-gu, Daegu, Republic of Korea.
FAU - Bae, Sang-Geun
AU  - Bae SG
FAU - Lee, Seon-Hwa
AU  - Lee SH
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
FAU - Lee, Duk-Hee
AU  - Lee DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130625
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Benzofurans)
RN  - 0 (Dibenzofurans, Polychlorinated)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
RN  - 0 (Pesticides)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 4R7X1O2820 (Chlorine)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Benzofurans/blood
MH  - Chlorine/blood
MH  - Cross-Sectional Studies
MH  - Dibenzofurans, Polychlorinated
MH  - Dioxins/blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hyperuricemia/*blood/*epidemiology
MH  - Male
MH  - Metabolic Syndrome/blood
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Odds Ratio
MH  - Organic Chemicals/blood
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Polychlorinated Dibenzodioxins/analogs & derivatives/blood
MH  - Risk Factors
MH  - United States
MH  - Young Adult
OTO - NOTNLM
OT  - CDC
OT  - Centers for Disease Control and Prevention
OT  - Dioxin
OT  - Hyperuricemia
OT  - LOD
OT  - MetS
OT  - NHANES
OT  - National Health and Nutrition Examination Survey
OT  - OC pesticides
OT  - ORs
OT  - Organochlorine pesticides
OT  - PCBs
OT  - PCDDs
OT  - PCDFs
OT  - POPs
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyls
OT  - TEFs
OT  - UA
OT  - limit of detection
OT  - metabolic syndrome
OT  - odds ratios
OT  - organochlorine pesticides
OT  - persistent organic pollutants
OT  - polychlorinated biphenyls
OT  - polychlorinated dibenzo-p-dioxins
OT  - polychlorinated dibenzofurans
OT  - toxic equivalency factors
OT  - uric acid
EDAT- 2013/08/21 06:00
MHDA- 2014/03/25 06:00
CRDT- 2013/08/21 06:00
PHST- 2012/09/23 00:00 [received]
PHST- 2013/05/02 00:00 [revised]
PHST- 2013/06/13 00:00 [accepted]
PHST- 2013/08/21 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2014/03/25 06:00 [medline]
AID - S0021-9150(13)00378-X [pii]
AID - 10.1016/j.atherosclerosis.2013.06.012 [doi]
PST - ppublish
SO  - Atherosclerosis. 2013 Sep;230(1):1-5. doi: 10.1016/j.atherosclerosis.2013.06.012. 
      Epub 2013 Jun 25.