PMID- 23958449
OWN - NLM
STAT- MEDLINE
DCOM- 20140819
LR  - 20191210
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 75
DP  - 2013 Dec
TI  - Exogenous BDNF facilitates strategy set-shifting by modulating glutamate dynamics 
      in the dorsal striatum.
PG  - 312-23
LID - S0028-3908(13)00350-X [pii]
LID - 10.1016/j.neuropharm.2013.07.033 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) signaling via tropomyosin-related kinase 
      B (trkB) receptors exerts modulatory effects on glutamatergic transmission, 
      learning, memory and reward processing. Although the role of BDNF in the 
      regulation of mnemonic and affective/motivational processes is well studied, 
      whether this neurotrophin could also regulate executive functions is not known. 
      In the present study, we assessed the effects of intrastriatal infusions on BDNF 
      (1-100 ng/hemisphere) in mice performing an operant strategy set-shifting task 
      that required the animals to eliminate a visual cue-based strategy and adopt a 
      new egocentric spatial response strategy to achieve rewards. Exogenous BDNF 
      administration facilitated the acquisition of strategy shifting by minimizing 
      response perseveration to the previously acquired strategy and this effect 
      resemble an inverted-U shaped dose-response pattern. Faster acquisition of 
      strategy switching in BDNF-infused animals was dependent upon the activation of 
      striatal trkB receptors. Moreover, activation of mGluR2/3 receptors by the 
      selective group II metabotropic receptor agonist LY379268 abolished BDNF-induced 
      cognitive enhancement suggesting the involvement of presynaptic glutamatergic 
      activity. Assessment of striatal glutamate dynamics using electrochemical 
      recordings indicated that local application of BDNF directly induces glutamate 
      release by activating presynaptic trkB receptors on glutamatergic terminals, and 
      this effect followed a bell-shaped dose-response pattern similar to strategy 
      shifting performance. These data suggest that activation of BDNF-trkB signaling 
      in the dorsal striatum improves strategy switching by effectively minimizing 
      response conflicts, and this effect primarily involves facilitation of 
      glutamatergic transmission.
CI  - Published by Elsevier Ltd.
FAU - D'Amore, Drew E
AU  - D'Amore DE
AD  - Department of Psychology and Neuroscience Program, Temple University, 1701 N. 
      13th Street, Weiss Hall, Philadelphia, PA 19122, USA.
FAU - Tracy, Brittany A
AU  - Tracy BA
AD  - Department of Psychology and Neuroscience Program, Temple University, 1701 N. 
      13th Street, Weiss Hall, Philadelphia, PA 19122, USA.
FAU - Parikh, Vinay
AU  - Parikh V
AD  - Department of Psychology and Neuroscience Program, Temple University, 1701 N. 
      13th Street, Weiss Hall, Philadelphia, PA 19122, USA. Electronic address: 
      vinay.parikh@temple.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130816
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Amino Acids)
RN  - 0 (Anesthetics, Local)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Bridged Bicyclo Compounds, Heterocyclic)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Excitatory Amino Acid Agents)
RN  - 0 (LY 379268)
RN  - 4368-28-9 (Tetrodotoxin)
SB  - IM
MH  - Amino Acids/pharmacology
MH  - Anesthetics, Local/pharmacology
MH  - Animals
MH  - Attention/*drug effects
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Bridged Bicyclo Compounds, Heterocyclic/pharmacology
MH  - Cognition/drug effects
MH  - Conditioning, Operant/drug effects
MH  - Corpus Striatum/*drug effects/physiology
MH  - Cues
MH  - Discrimination, Psychological/drug effects
MH  - Enzyme Inhibitors/pharmacology
MH  - Excitatory Amino Acid Agents/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Photic Stimulation
MH  - Reaction Time/drug effects
MH  - *Set, Psychology
MH  - Tetrodotoxin/pharmacology
OTO - NOTNLM
OT  - BDNF
OT  - Cognitive flexibility
OT  - Dorsal striatum
OT  - Glutamate
EDAT- 2013/08/21 06:00
MHDA- 2014/08/20 06:00
CRDT- 2013/08/21 06:00
PHST- 2013/06/26 00:00 [received]
PHST- 2013/07/29 00:00 [revised]
PHST- 2013/07/30 00:00 [accepted]
PHST- 2013/08/21 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2014/08/20 06:00 [medline]
AID - S0028-3908(13)00350-X [pii]
AID - 10.1016/j.neuropharm.2013.07.033 [doi]
PST - ppublish
SO  - Neuropharmacology. 2013 Dec;75:312-23. doi: 10.1016/j.neuropharm.2013.07.033. 
      Epub 2013 Aug 16.