PMID- 23958502
OWN - NLM
STAT- MEDLINE
DCOM- 20140508
LR  - 20131007
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 553
DP  - 2013 Oct 11
TI  - Differential effects of exercise intensities in hippocampal BDNF, inflammatory 
      cytokines and cell proliferation in rats during the postnatal brain development.
PG  - 1-6
LID - S0304-3940(13)00748-9 [pii]
LID - 10.1016/j.neulet.2013.08.015 [doi]
AB  - It has been established that low intensities of exercise produce beneficial 
      effects for the brain, while high intensities can cause some neuronal damage 
      (e.g. exacerbated inflammatory response and cell death). Although these effects 
      are documented in the mature brain, the influence of exercise intensities in the 
      developing brain has been poorly explored. To investigate the impact of exercise 
      intensity in developing rats, we evaluated the hippocampal level of brain derived 
      neurotrophic factor (BDNF), inflammatory cytokines (TNFalpha, IL6 and IL10) and the 
      occurrence of hippocampal cell degeneration and proliferation at different stages 
      of postnatal brain development of rats submitted to two physical exercise 
      intensities. To this point, male rats were divided into different age groups: 
      P21, P31, P41 and P51. Each age group was submitted to two exercise intensities 
      (low and high) on a treadmill over 10 consecutive days, except the control rats. 
      We verified that the density of proliferating cells was significantly higher in 
      the dentate gyrus of rats submitted to low-intensity exercise from P21 to P30 
      compared with high-intensity exercise and control rats. A significant increase of 
      proliferative cell density was found in rats submitted to high-intensity exercise 
      from P31 to P40 when compared to low-intensity exercise and control rats. 
      Elevated hippocampal levels of IL6 were detected in rats submitted to 
      high-intensity exercise from P21 to P30 compared to control rats. From P41 to P50 
      period, higher levels of BDNF, TNFalpha and IL10 were found in the hippocampal 
      formation of rats submitted to high-intensity exercise in relation to their 
      control rats. Our data show that exercise-induced neuroplastic effects on BDNF 
      levels and cellular proliferation in the hippocampal region are dependent on 
      exercise intensity and developmental period. Thus, exercise intensity is an 
      inflammation-inducing factor and exercise-induced inflammatory response during 
      the postnatal brain development is also related to developmental stage. Our 
      findings indicate that neuroplastic changes induced by exercise in developing 
      rats depend on both age and training intensity.
CI  - Crown Copyright (c) 2013. Published by Elsevier Ireland Ltd. All rights reserved.
FAU - de Almeida, Alexandre Aparecido
AU  - de Almeida AA
AD  - Department of Physiology, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, 
      SP, Brazil.
FAU - Gomes da Silva, Sergio
AU  - Gomes da Silva S
FAU - Fernandes, Jansen
AU  - Fernandes J
FAU - Peixinho-Pena, Luiz Fernando
AU  - Peixinho-Pena LF
FAU - Scorza, Fulvio Alexandre
AU  - Scorza FA
FAU - Cavalheiro, Esper Abrao
AU  - Cavalheiro EA
FAU - Arida, Ricardo Mario
AU  - Arida RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130817
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Proliferation
MH  - Cytokines/*metabolism
MH  - Dentate Gyrus/cytology/growth & development/metabolism
MH  - Hippocampus/*cytology/growth & development/*metabolism
MH  - Male
MH  - Neurons/cytology/metabolism
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
OTO - NOTNLM
OT  - Brain
OT  - Development
OT  - Exercise
OT  - Inflammation
OT  - Intensity
OT  - Plasticity
EDAT- 2013/08/21 06:00
MHDA- 2014/05/09 06:00
CRDT- 2013/08/21 06:00
PHST- 2013/05/25 00:00 [received]
PHST- 2013/08/07 00:00 [revised]
PHST- 2013/08/08 00:00 [accepted]
PHST- 2013/08/21 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2014/05/09 06:00 [medline]
AID - S0304-3940(13)00748-9 [pii]
AID - 10.1016/j.neulet.2013.08.015 [doi]
PST - ppublish
SO  - Neurosci Lett. 2013 Oct 11;553:1-6. doi: 10.1016/j.neulet.2013.08.015. Epub 2013 
      Aug 17.