PMID- 23958764
OWN - NLM
STAT- MEDLINE
DCOM- 20131030
LR  - 20150915
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 132
IP  - 3
DP  - 2013 Sep
TI  - Probiotic administration in early life, atopy, and asthma: a meta-analysis of 
      clinical trials.
PG  - e666-76
LID - 10.1542/peds.2013-0246 [doi]
AB  - BACKGROUND AND OBJECTIVE: Probiotics may reduce the risk of atopy and asthma in 
      children. However, results from clinical trials have been conflicting, and 
      several of them may have been underpowered. We performed a meta-analysis of 
      randomized, placebo-controlled trials to assess the effects of probiotic 
      supplementation on atopic sensitization and asthma/wheeze prevention in children. 
      METHODS: Random-effects models were used to calculate pooled risk estimates. 
      Meta-regression was conducted to examine the effect of potential factors on 
      probiotics efficacy. RESULTS: Probiotics were effective in reducing total 
      immunoglobulin E (IgE) (mean reduction: -7.59 U/mL [95% confidence interval (CI): 
      -14.96 to -0.22]; P = .044). Meta-regression showed that the reduction in IgE was 
      more pronounced with longer follow-up. Probiotics significantly reduced the risk 
      of atopic sensitization when administered prenatally (relative risk: 0.88 [95% 
      CI: 0.78 to 0.99]; P = .035 for positive result on the skin prick test and/or 
      elevated specific IgE to common allergens) and postnatally (relative risk: 0.86 
      [95% CI: 0.75 to 0.98]; P = .027 for positive result on skin prick test). 
      Administration of Lactobacillus acidophilus, compared with other strains, was 
      associated with an increased risk of atopic sensitization (P = .002). Probiotics 
      did not significantly reduce asthma/wheeze (relative risk: 0.96 [95% CI: 0.85 to 
      1.07]). CONCLUSIONS: Prenatal and/or early-life probiotic administration reduces 
      the risk of atopic sensitization and decreases the total IgE level in children 
      but may not reduce the risk of asthma/wheeze. Follow-up duration and strain 
      significantly modified these effects. Future trials for asthma prevention should 
      carefully select probiotic strain and consider longer follow-up.
FAU - Elazab, Nancy
AU  - Elazab N
AD  - Division of Pediatric Pulmonology, Department of Pediatrics, University of Miami, 
      Miami, FL, USA.
FAU - Mendy, Angelico
AU  - Mendy A
FAU - Gasana, Janvier
AU  - Gasana J
FAU - Vieira, Edgar R
AU  - Vieira ER
FAU - Quizon, Annabelle
AU  - Quizon A
FAU - Forno, Erick
AU  - Forno E
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20130819
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/immunology/*prevention & control
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/immunology/*prevention & control
MH  - Double-Blind Method
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Pregnancy
MH  - Probiotics/*administration & dosage
MH  - Randomized Controlled Trials as Topic
MH  - Respiratory Hypersensitivity/immunology/*prevention & control
MH  - Risk
MH  - Treatment Outcome
OTO - NOTNLM
OT  - atopic sensitization
OT  - childhood asthma
OT  - childhood atopy
OT  - intestinal microbiome
OT  - meta-analysis
OT  - probiotics
OT  - total IgE
EDAT- 2013/08/21 06:00
MHDA- 2013/10/31 06:00
CRDT- 2013/08/21 06:00
PHST- 2013/08/21 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2013/10/31 06:00 [medline]
AID - peds.2013-0246 [pii]
AID - 10.1542/peds.2013-0246 [doi]
PST - ppublish
SO  - Pediatrics. 2013 Sep;132(3):e666-76. doi: 10.1542/peds.2013-0246. Epub 2013 Aug 
      19.