PMID- 23959583
OWN - NLM
STAT- MEDLINE
DCOM- 20140718
LR  - 20211021
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 98
IP  - 4
DP  - 2013 Oct
TI  - Diagnostic challenges in a case of B cell lymphoma unclassifiable with features 
      intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma.
PG  - 478-82
AB  - Unclassifiable B-cell lymphoma with features intermediate between diffuse large 
      B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) is a recently recognized 
      category of mature B-cell lymphoma. This represents a heterogeneous group of 
      diseases which often pose diagnostic problems in clinical practice, yet its 
      distinction from DLBCL to BL is important for its therapeutic and prognostic 
      implications. We report the challenging diagnostic process of a 60-year-old man. 
      He had a CD10 and BCL2-positive, BCL6-negative B-cell malignancy with loss of 
      multiple B-cell markers including surface immunoglobulin. The karyotype was 
      complex and unusual, including t(2;18)(p12;q21), t(8;14)(q24;q32) and a 
      derivative chromosome 22 mimicking a Philadelphia chromosome that led to initial 
      diagnostic confusion. A triple-hit gray zone B-cell lymphoma with rearrangements 
      of MYC, BCL2, BCL6, both alleles of IGH and likely IGK and IGL was finally 
      diagnosed upon additional fluorescence in situ hybridization (FISH) studies. His 
      disease was nonresponsive to intensive combination chemotherapy and he died 4 
      months after presentation. This case illustrates the diagnostic difficulty 
      encountered in such group of B-cell lymphomas and emphasizes the need to 
      integrate morphological, immunophenotypic and genetic data in making a diagnosis.
FAU - So, Chi-Chiu
AU  - So CC
FAU - Yung, Ka-Hung
AU  - Yung KH
FAU - Chu, Man-Leng
AU  - Chu ML
FAU - Wan, Thomas S K
AU  - Wan TS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
SB  - IM
MH  - Bone Marrow/pathology
MH  - Burkitt Lymphoma/*diagnosis/drug therapy/genetics/pathology
MH  - Diagnosis, Differential
MH  - Fatal Outcome
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotype
MH  - Lymphoma, Large B-Cell, Diffuse/*diagnosis/drug therapy/genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Phenotype
EDAT- 2013/08/21 06:00
MHDA- 2014/07/19 06:00
CRDT- 2013/08/21 06:00
PHST- 2013/05/13 00:00 [received]
PHST- 2013/08/06 00:00 [accepted]
PHST- 2013/08/05 00:00 [revised]
PHST- 2013/08/21 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2014/07/19 06:00 [medline]
AID - 10.1007/s12185-013-1414-9 [doi]
PST - ppublish
SO  - Int J Hematol. 2013 Oct;98(4):478-82. doi: 10.1007/s12185-013-1414-9.