PMID- 23960204
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20201209
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 25
IP  - 1
DP  - 2015 Jan
TI  - Abnormal retinoid and TrkB signaling in the prefrontal cortex in mood disorders.
PG  - 75-83
LID - 10.1093/cercor/bht203 [doi]
AB  - The prefrontal cortex shows structural and functional alterations in mood 
      disorders. Retinoid signaling, brain-derived neurotrophic factor (BDNF), and its 
      receptor TrkB are reported to be involved in depression. Here, we found that mRNA 
      levels of key elements of retinoid signaling were significantly reduced in the 
      postmortem dorsolateral prefrontal cortex/anterior cingulate cortex (ACC) from 
      elderly depressed patients who did not die from suicide. Decreased mRNA levels of 
      BDNF and TrkB isoforms were also found. Similar alterations were observed in rats 
      subjected to chronic unpredictable mild stress. Along with neurons immunopositive 
      for both retinoic acid receptor-alpha (RARalpha) and TrkB, a positive correlation between 
      mRNA levels of the 2 receptors was found in the ACC of control subjects but not 
      of depressed patients. In vitro studies showed that RARalpha was able to bind to and 
      transactivate the TrkB promoter via a putative RA response element within the 
      TrkB promoter. In conclusion, the retinoid and BDNF-TrkB signaling in the 
      prefrontal cortex are compromised in mood disorders, and the transcriptional 
      upregulation of TrkB by RARalpha provide a possible mechanism for their interaction. 
      The retinoid signaling pathway that may activate TrkB expression will be an 
      alternative novel target for BDNF-based antidepressant treatment.
CI  - (c) The Author 2013. Published by Oxford University Press. All rights reserved. For 
      Permissions, please e-mail: journals.permissions@oup.com.
FAU - Qi, Xin-Rui
AU  - Qi XR
AD  - CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, 
      University of Science and Technology of China, Hefei, Anhui 230026, PR China 
      Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands 
      Academy of Arts and Sciences, Amsterdam 1105BA, The Netherlands.
FAU - Zhao, Jun
AU  - Zhao J
AD  - CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, 
      University of Science and Technology of China, Hefei, Anhui 230026, PR China.
FAU - Liu, Ji
AU  - Liu J
AD  - CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, 
      University of Science and Technology of China, Hefei, Anhui 230026, PR China.
FAU - Fang, Hui
AU  - Fang H
AD  - CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, 
      University of Science and Technology of China, Hefei, Anhui 230026, PR China.
FAU - Swaab, Dick F
AU  - Swaab DF
AD  - Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands 
      Academy of Arts and Sciences, Amsterdam 1105BA, The Netherlands.
FAU - Zhou, Jiang-Ning
AU  - Zhou JN
AD  - CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, 
      University of Science and Technology of China, Hefei, Anhui 230026, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130819
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Retinoid X Receptor alpha)
RN  - 0 (Retinoid X Receptor beta)
RN  - 0 (Retinoid X Receptors)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 1.2.- (Aldehyde Oxidoreductases)
RN  - EC 1.2.1 (Aldehyde Dehydrogenase 1 Family)
RN  - EC 1.2.1.3 (Aldehyde Dehydrogenase)
RN  - EC 1.2.1.36 (ALDH1A1 protein, human)
RN  - EC 1.2.1.36 (Retinal Dehydrogenase)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (tropomyosin-related kinase-B, human)
SB  - IM
MH  - Aged
MH  - Aldehyde Dehydrogenase/metabolism
MH  - Aldehyde Dehydrogenase 1 Family
MH  - Aldehyde Oxidoreductases/metabolism
MH  - Animals
MH  - Bipolar Disorder/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - CHO Cells
MH  - Cell Line, Tumor
MH  - Cricetulus
MH  - Depressive Disorder, Major/*metabolism
MH  - Female
MH  - Gyrus Cinguli/metabolism
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*metabolism
MH  - Neuroblastoma
MH  - Neurons/metabolism
MH  - Prefrontal Cortex/*metabolism
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB
MH  - Retinal Dehydrogenase
MH  - Retinoid X Receptor alpha/metabolism
MH  - Retinoid X Receptor beta/metabolism
MH  - Retinoid X Receptors/*metabolism
MH  - Signal Transduction
MH  - Stress, Psychological/metabolism
OTO - NOTNLM
OT  - anterior cingulate cortex
OT  - brain-derived neurotrophic factor
OT  - dorsolateral prefrontal cortex
OT  - mood disorder
OT  - retinoic acid receptor-alpha
EDAT- 2013/08/21 06:00
MHDA- 2015/04/07 06:00
CRDT- 2013/08/21 06:00
PHST- 2013/08/21 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - bht203 [pii]
AID - 10.1093/cercor/bht203 [doi]
PST - ppublish
SO  - Cereb Cortex. 2015 Jan;25(1):75-83. doi: 10.1093/cercor/bht203. Epub 2013 Aug 19.