PMID- 23960436
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20211021
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 28
IP  - 8
DP  - 2013 Aug
TI  - Associations between cigarette smoking and total mortality differ depending on 
      serum concentrations of persistent organic pollutants among the elderly.
PG  - 1122-8
LID - 10.3346/jkms.2013.28.8.1122 [doi]
AB  - There are substantial variations of relative risks (RR) in smoking-related 
      mortality by country and time. We hypothesized the RRs in smoking-related 
      mortality might differ depending on serum concentrations of persistent organic 
      pollutants (POPs). We evaluated the associations of cigarette smoking with total 
      mortality in 610 elderly (aged >/= 70 yr) (702 elderly for organochlorine 
      pesticides [OCPs]) after stratification by serum concentration of POPs, in the 
      National Health and Nutrition Examination Survey (NHANES) 1999-2004 followed 
      through 2006. Summary measures of POPs subclasses showed significant or 
      marginally significant interaction with cigarette smoking on the risk of total 
      mortality. P values for interaction were 0.069 for polychlorinated 
      dibenzo-p-dioxins (PCDDs), 0.008 for polychlorinated biphenyls (PCBs), and 0.024 
      for OCPs. The effect of smoking on total mortality showed different patterns 
      according to the serum concentration of some POPs. Former or current smokers had 
      1.4 to 2.9 times higher mortality rates compared with never smokers among 
      participants with higher serum concentrations of POPs (2nd or 3rd tertiles). 
      However, when the level of PCBs or OCPs were low (1st tertile), there were little 
      positive associations between smoking and mortality. Our study suggests that the 
      background exposure to several POPs may be related to variability in 
      smoking-related total mortality.
FAU - Lee, Yu-Mi
AU  - Lee YM
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea.
FAU - Bae, Sang-Geun
AU  - Bae SG
FAU - Lee, Seon-Hwa
AU  - Lee SH
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
FAU - Lee, Duk-Hee
AU  - Lee DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130731
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Environmental Exposure
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Male
MH  - Nutrition Surveys
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Polychlorinated Dibenzodioxins/analogs & derivatives/blood
MH  - Proportional Hazards Models
MH  - Risk
MH  - Smoking/*mortality
PMC - PMC3744697
OTO - NOTNLM
OT  - Mortality
OT  - Organochlorine Pesticides
OT  - Persistent Organic Pollutants
OT  - Polychlorinated Biphenyls
OT  - Smoking
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2013/08/21 06:00
MHDA- 2014/04/04 06:00
PMCR- 2013/08/01
CRDT- 2013/08/21 06:00
PHST- 2013/02/26 00:00 [received]
PHST- 2013/05/22 00:00 [accepted]
PHST- 2013/08/21 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - 10.3346/jkms.2013.28.8.1122 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2013 Aug;28(8):1122-8. doi: 10.3346/jkms.2013.28.8.1122. Epub 
      2013 Jul 31.