PMID- 23960662
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130820
LR  - 20211021
IS  - 1016-7315 (Print)
IS  - 2212-5043 (Electronic)
IS  - 1016-7315 (Linking)
VI  - 24
IP  - 1
DP  - 2012 Jan
TI  - Age and its relationship to acute coronary syndromes in the Saudi Project for 
      Assessment of Coronary Events (SPACE) registry: The SPACE age study.
PG  - 9-16
LID - 10.1016/j.jsha.2011.08.001 [doi]
AB  - OBJECTIVE: To characterize risk profile of acute coronary syndrome (ACS) patients 
      in different age groups and compare management provided to in-hospital outcome. 
      DESIGN: Prospective multi-hospital registry. SETTING: Seventeen secondary and 
      tertiary care hospitals in Saudi Arabia. PATIENTS: Five thousand and fifty-five 
      patients with ACS. They were divided into four groups: ⩽40 years, 41-55 years, 
      56-70 years and ⩾70 years. MAIN OUTCOME MEASURES: prevalence, utilization and 
      mortality. RESULTS: Ninety-four percent of patients <40 years compared to 68% of 
      patients >70 years were men. Diabetes was present in 70% of patients aged 
      56-70 years. Smoking was present in 66% of those <40 years compared to 7% of 
      patients >70 years. Fifty-three percent of the patients >70 years and 25% of 
      those <40 years had history of ischemic heart disease. Sixty percent of patients 
      <40 years presented with ST elevation myocardial infarction (STEMI) while non-ST 
      elevation myocardial infarction was the presentation in 49% of patients 
      >70 years. Thirty-four percent of patients >70 years compared to 10% of patients 
      <40 years presented >12 h from symptom onset with STEMI. Fifty-four percent of 
      patients >70 compared to 64-71% of those <70 years had coronary angiography. 
      Twenty-four percent of patients >70 compared to 34-40% of those <70 years had 
      percutaneous coronary intervention. Reperfusion shortfall for STEMI was 16-18% in 
      patients >56 years compared to 11% in patients <40 years. Mortality was 7% in 
      patients >70 years compared to 1.6-3% in patients <70 years. For all comparisons 
      (p < 0.001). CONCLUSIONS: Young and old ACS patients have unique risk factors and 
      present differently. Older patients have higher in-hospital mortality as they are 
      treated less aggressively. There is an urgent need for a national prevention 
      program as well as a systematic improvement in the care for patients with ACS 
      including a system of care for STEMI patients. For older patients there is a need 
      to identify medical as well as social factors that influence the therapeutic 
      management plans.
FAU - Al-Saif, Shukri M
AU  - Al-Saif SM
AD  - Saud AlBabtain Cardiac Center, Dammam.
FAU - Alhabib, Khalid F
AU  - Alhabib KF
FAU - Ullah, Anhar
AU  - Ullah A
FAU - Hersi, Ahmed
AU  - Hersi A
FAU - Alfaleh, Husam
AU  - Alfaleh H
FAU - Alnemer, Khalid
AU  - Alnemer K
FAU - Tarabin, Amir
AU  - Tarabin A
FAU - Abuosa, Ahmed
AU  - Abuosa A
FAU - Kashour, Tarek
AU  - Kashour T
FAU - Al-Murayeh, Mushabab
AU  - Al-Murayeh M
LA  - eng
PT  - Journal Article
DEP - 20111019
PL  - Saudi Arabia
TA  - J Saudi Heart Assoc
JT  - Journal of the Saudi Heart Association
JID - 9887261
PMC - PMC3727458
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Age
OT  - In-hospital outcome
OT  - Mortality
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
PMCR- 2011/10/19
CRDT- 2013/08/21 06:00
PHST- 2011/03/31 00:00 [received]
PHST- 2011/06/19 00:00 [revised]
PHST- 2011/08/01 00:00 [accepted]
PHST- 2013/08/21 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
PHST- 2011/10/19 00:00 [pmc-release]
AID - JSHA129 [pii]
AID - 10.1016/j.jsha.2011.08.001 [doi]
PST - ppublish
SO  - J Saudi Heart Assoc. 2012 Jan;24(1):9-16. doi: 10.1016/j.jsha.2011.08.001. Epub 
      2011 Oct 19.