PMID- 23961408
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130820
LR  - 20211021
IS  - 2193-1801 (Print)
IS  - 2193-1801 (Electronic)
IS  - 2193-1801 (Linking)
VI  - 2
DP  - 2013
TI  - Effect of gene polymorphisms on the mechanical properties of human tendon 
      structures.
PG  - 343
LID - 10.1186/2193-1801-2-343 [doi]
LID - 343
AB  - Recent studies showed that polymorphisms in alpha 1 chains of types I (COL1A1) 
      and V (COL5A1) collagen, growth and differentiation factor 5 (GDF5), and matrix 
      metalloproteinase 3 (MMP3) genes were associated with injuries in tendons and 
      ligaments (e.g., September et al. (Br J Sports Med 43: 357-365 2009)). In the 
      present study, we aimed to investigate the effects of injury-associated 
      polymorphisms within these four genes on the mechanical properties of human 
      tendon structures in vivo. One hundred Japanese males participated in this 
      experiment. The mechanical properties of tendon structures in knee extensors and 
      plantar flexors were measured using ultrasonography. All subjects were genotyped 
      for COL1A1 rs1800012, COL5A1 rs12722, GDF5 rs143383, and MMP3 rs679620 single 
      nucleotide polymorphisms. For COL1A1, all subjects had a GG genotype. For COL5A1, 
      maximal tendon elongation and strain of individuals with a CC genotype were 
      significantly greater than individuals with other genotypes (combined TT and CT) 
      for knee extensors, but not for plantar flexors. For GDF5 and MMP3, there were no 
      differences in the mechanical properties of tendon structures in knee extensors 
      and plantar flexors among the three genotypes. The present study demonstrated 
      that subjects with a CC genotype of the COL5A1 gene had more extensible tendon 
      structures than those of subjects with other genotypes (combined TT and CT) for 
      knee extensors, but not for plantar flexors. The results presented in this study 
      need to be confirmed in a larger cohort of subjects.
FAU - Kubo, Keitaro
AU  - Kubo K
AD  - Department of Life Science (Sports Sciences), University of Tokyo, Komaba 3-8-1, 
      Meguro-ku, Tokyo, 153-8902 Japan.
FAU - Yata, Hideaki
AU  - Yata H
FAU - Tsunoda, Naoya
AU  - Tsunoda N
LA  - eng
PT  - Journal Article
DEP - 20130725
PL  - Switzerland
TA  - Springerplus
JT  - SpringerPlus
JID - 101597967
PMC - PMC3728528
OTO - NOTNLM
OT  - Collagen
OT  - Stiffness
OT  - Strain
OT  - Ultrasonography
EDAT- 2013/08/21 06:00
MHDA- 2013/08/21 06:01
PMCR- 2013/07/25
CRDT- 2013/08/21 06:00
PHST- 2013/06/17 00:00 [received]
PHST- 2013/07/23 00:00 [accepted]
PHST- 2013/08/21 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2013/08/21 06:01 [medline]
PHST- 2013/07/25 00:00 [pmc-release]
AID - 406 [pii]
AID - 10.1186/2193-1801-2-343 [doi]
PST - epublish
SO  - Springerplus. 2013 Jul 25;2:343. doi: 10.1186/2193-1801-2-343. eCollection 2013.