PMID- 23962021
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20211203
IS  - 1520-6025 (Electronic)
IS  - 0163-3864 (Linking)
VI  - 76
IP  - 9
DP  - 2013 Sep 27
TI  - Protective mechanism of anethole on hepatic ischemia/reperfusion injury in mice.
PG  - 1717-23
LID - 10.1021/np4004323 [doi]
AB  - The aim of this study was to investigate the hepatoprotective effect of anethole 
      (trans-anethole, 1), a major component of Foeniculum vulgare, and its molecular 
      mechanism during ischemia/reperfusion (I/R). Mice were subjected to 60 min of 
      partial hepatic ischemia followed by 1 and 6 h of reperfusion. Compound 1 (50, 
      100, and 200 mg/kg) or the vehicle alone (10% Tween 80-saline) was orally 
      administered 1 h prior to ischemia. After 1 and 6 h of reperfusion, serum alanine 
      aminotransferase, tumor necrosis factor-alpha, and interleukin 6 levels significantly 
      increased, but these increases were attenuated by 1. Nuclear translocation of 
      interferon regulatory factor (IRF)-1, release of high mobility group box (HMGB) 1 
      into the extracellular milieu, and the interactions between IRF-1 and histone 
      acetyltransferase p300 increased after I/R. These increases were attenuated by 1. 
      Compound 1 suppressed increases in toll-like receptor (TLR) 4, myeloid 
      differentiation primary response gene 88 protein expression, phosphorylation of 
      p38, extracellular signal-regulated kinase, c-Jun N-terminal kinase, nuclear 
      translocation of nuclear factor kappa B, and phosphorylated c-Jun. The present 
      findings suggest that 1 protects against hepatic I/R injury by suppression of 
      IRF-1-mediated HMGB1 release and subsequent TLR activation.
FAU - Cho, Hong-Ik
AU  - Cho HI
AD  - School of Pharmacy, Sungkyunkwan University , Suwon, Gyeonggi-do, 440-746, 
      Republic of Korea.
FAU - Kim, Kang-Min
AU  - Kim KM
FAU - Kwak, Jong Hwan
AU  - Kwak JH
FAU - Lee, Sang Kook
AU  - Lee SK
FAU - Lee, Sun-Mee
AU  - Lee SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130820
PL  - United States
TA  - J Nat Prod
JT  - Journal of natural products
JID - 7906882
RN  - 0 (Allylbenzene Derivatives)
RN  - 0 (Anisoles)
RN  - 0 (HMGB Proteins)
RN  - 0 (HMGB1 Protein)
RN  - 0 (Interferon Regulatory Factor-1)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - Q3JEK5DO4K (anethole)
SB  - IM
MH  - Allylbenzene Derivatives
MH  - Animals
MH  - Anisoles/chemistry/*pharmacology
MH  - Blotting, Western
MH  - Fruit/chemistry
MH  - HMGB Proteins/metabolism
MH  - HMGB1 Protein/metabolism
MH  - Interferon Regulatory Factor-1/genetics
MH  - Interleukin-6/analysis/blood
MH  - Ischemia/pathology
MH  - JNK Mitogen-Activated Protein Kinases/drug effects/metabolism
MH  - Liver/*pathology
MH  - MAP Kinase Signaling System/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Molecular Structure
MH  - NF-kappa B/drug effects
MH  - Reperfusion Injury/*blood/immunology/*pathology
MH  - Republic of Korea
MH  - Toll-Like Receptor 4/drug effects/metabolism
MH  - Tumor Necrosis Factor-alpha/analysis/blood
EDAT- 2013/08/22 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/08/22 06:00
PHST- 2013/08/22 06:00 [entrez]
PHST- 2013/08/22 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.1021/np4004323 [doi]
PST - ppublish
SO  - J Nat Prod. 2013 Sep 27;76(9):1717-23. doi: 10.1021/np4004323. Epub 2013 Aug 20.