PMID- 23962825
OWN - NLM
STAT- MEDLINE
DCOM- 20140911
LR  - 20220318
IS  - 1873-2615 (Electronic)
IS  - 1050-1738 (Print)
IS  - 1050-1738 (Linking)
VI  - 24
IP  - 2
DP  - 2014 Feb
TI  - Functional role, mechanisms of regulation, and therapeutic potential of regulator 
      of G protein signaling 2 in the heart.
PG  - 85-93
LID - S1050-1738(13)00113-8 [pii]
LID - 10.1016/j.tcm.2013.07.002 [doi]
AB  - G protein-mediated signal transduction is essential for the regulation of 
      cardiovascular function, including heart rate, growth, contraction, and vascular 
      tone. Regulators of G protein Signaling (RGS proteins) fine-tune G 
      protein-coupled receptor-induced signaling by regulating its magnitude and 
      duration through direct interaction with the alpha subunits of heterotrimeric G 
      proteins. Changes in the RGS protein expression and/or function in the heart 
      often lead to pathophysiological changes and are associated with cardiac disease 
      in animals and humans, including hypertrophy, fibrosis development, heart 
      failure, and arrhythmias. This article focuses on Regulator of G protein 
      Signaling 2 (RGS2), which is widely expressed in many tissues and is highly 
      regulated in its expression and function. Most information to date has been 
      obtained in biochemical, cellular, and animal studies, but data from humans is 
      emerging. We review recent advances on the functional role of cardiovascular RGS2 
      and the mechanisms that determine its signaling selectivity, expression, and 
      functionality. We highlight key unanswered questions and discuss the potential of 
      RGS2 as a therapeutic target.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Zhang, Peng
AU  - Zhang P
AD  - Cardiovascular Research Center, Cardiology Division, Rhode Island Hospital and 
      Alpert Medical School of Brown University, Providence, RI, USA.
FAU - Mende, Ulrike
AU  - Mende U
AD  - Cardiovascular Research Center, Cardiology Division, Rhode Island Hospital and 
      Alpert Medical School of Brown University, Providence, RI, USA. Electronic 
      address: ulrike_mende@brown.edu.
LA  - eng
GR  - R01 HL114784/HL/NHLBI NIH HHS/United States
GR  - R21 HL113918/HL/NHLBI NIH HHS/United States
GR  - 5P20RR018728-10/8P20GM103537-10/GM/NIGMS NIH HHS/United States
GR  - P20 GM103652/GM/NIGMS NIH HHS/United States
GR  - P20 GM103537/GM/NIGMS NIH HHS/United States
GR  - R01 HL080127/HL/NHLBI NIH HHS/United States
GR  - HL113918/HL/NHLBI NIH HHS/United States
GR  - HL80127/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130817
PL  - United States
TA  - Trends Cardiovasc Med
JT  - Trends in cardiovascular medicine
JID - 9108337
RN  - 0 (RGS Proteins)
RN  - 0 (RGS2 protein, human)
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/genetics/*metabolism/pathology/physiopathology/therapy
MH  - Humans
MH  - Molecular Targeted Therapy
MH  - Myocardium/*metabolism/pathology
MH  - RGS Proteins/genetics/*metabolism
MH  - *Signal Transduction
PMC - PMC3948174
MID - NIHMS517023
EDAT- 2013/08/22 06:00
MHDA- 2014/09/12 06:00
PMCR- 2015/02/01
CRDT- 2013/08/22 06:00
PHST- 2013/05/16 00:00 [received]
PHST- 2013/07/08 00:00 [revised]
PHST- 2013/07/10 00:00 [accepted]
PHST- 2013/08/22 06:00 [entrez]
PHST- 2013/08/22 06:00 [pubmed]
PHST- 2014/09/12 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - S1050-1738(13)00113-8 [pii]
AID - 10.1016/j.tcm.2013.07.002 [doi]
PST - ppublish
SO  - Trends Cardiovasc Med. 2014 Feb;24(2):85-93. doi: 10.1016/j.tcm.2013.07.002. Epub 
      2013 Aug 17.