PMID- 23963708
OWN - NLM
STAT- MEDLINE
DCOM- 20141007
LR  - 20140204
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 22
IP  - 2
DP  - 2014 Feb
TI  - Prenatal exposure to persistent organic pollutants and rapid weight gain and 
      overweight in infancy.
PG  - 488-96
LID - 10.1002/oby.20603 [doi]
AB  - OBJECTIVE: To examine the effects of prenatal exposure to persistent organic 
      pollutants (POPs) on rapid growth in the first 6 months of life and overweight at 
      14 months of age. DESIGN AND METHODS: In a Spanish birth cohort study, the POPs 
      dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB), and 
      polychlorinated biphenyls (PCBs-congeners 153, 138, 180) were measured in 
      maternal serum collected in the first trimester of pregnancy during 2003-2008. 
      Rapid growth was defined as a z-score weight gain >0.67 SD between 6 months of 
      age and birth. Overweight at 14 months was defined as a BMI z-score >/=85th 
      percentile. Generalized linear models examined the association between POPs and 
      rapid growth (N = 1285) and overweight (N = 1198). RESULTS: The analysis 
      population included 24% rapid growers and 30% overweight infants. DDE and HCB 
      were positively associated with rapid growth and with overweight. There was some 
      indication that infant sex and exclusive breastfeeding duration may modify the 
      effects of DDE, and that maternal prepregnancy BMI status may influence the 
      effects of HCB. PCBs were not related to postnatal growth. CONCLUSION: Prenatal 
      exposure to DDE and HCB may be associated with early postnatal growth. Further 
      research is needed to evaluate the persistence of these associations at older 
      ages.
CI  - Copyright (c) 2013 The Obesity Society.
FAU - Valvi, Damaskini
AU  - Valvi D
AD  - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; 
      Hospital de Mar Medical Research Institute (IMIM), Barcelona, Spain; CIBER 
      Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain; Department of 
      Experimental and Health Sciences, Pompeu Fabra University (UPF), Barcelona, 
      Spain.
FAU - Mendez, Michelle Ann
AU  - Mendez MA
FAU - Garcia-Esteban, Raquel
AU  - Garcia-Esteban R
FAU - Ballester, Ferran
AU  - Ballester F
FAU - Ibarluzea, Jesus
AU  - Ibarluzea J
FAU - Goni, Fernando
AU  - Goni F
FAU - Grimalt, Joan O
AU  - Grimalt JO
FAU - Llop, Sabrina
AU  - Llop S
FAU - Marina, Loreto Santa
AU  - Marina LS
FAU - Vizcaino, Esther
AU  - Vizcaino E
FAU - Sunyer, Jordi
AU  - Sunyer J
FAU - Vrijheid, Martine
AU  - Vrijheid M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20131015
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Environmental Pollutants)
RN  - 0 (Pesticide Residues)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Breast Feeding
MH  - Child Development/*drug effects
MH  - Cohort Studies
MH  - Dichlorodiphenyl Dichloroethylene/blood/toxicity
MH  - Environmental Pollutants/blood/*toxicity
MH  - Female
MH  - Growth Disorders/*chemically induced/epidemiology
MH  - Hexachlorobenzene/blood/toxicity
MH  - Humans
MH  - Infant
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Overweight/*chemically induced/epidemiology
MH  - Pesticide Residues/blood
MH  - Pregnancy
MH  - Pregnancy Trimester, Third/blood
MH  - *Prenatal Exposure Delayed Effects
MH  - Prevalence
MH  - Prospective Studies
MH  - Spain/epidemiology
MH  - Weight Gain/*drug effects
EDAT- 2013/08/22 06:00
MHDA- 2014/10/08 06:00
CRDT- 2013/08/22 06:00
PHST- 2013/04/08 00:00 [received]
PHST- 2013/08/11 00:00 [accepted]
PHST- 2013/08/22 06:00 [entrez]
PHST- 2013/08/22 06:00 [pubmed]
PHST- 2014/10/08 06:00 [medline]
AID - 10.1002/oby.20603 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2014 Feb;22(2):488-96. doi: 10.1002/oby.20603. Epub 2013 
      Oct 15.