PMID- 23964182
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130821
LR  - 20211021
IS  - 1319-4534 (Print)
IS  - 1319-4534 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Jan
TI  - Discriminating ability of spectral domain optical coherence tomography in 
      different stages of glaucoma.
PG  - 19-24
LID - 10.1016/j.sjopt.2012.09.001 [doi]
AB  - PURPOSE: To determine the discriminating ability of retinal nerve fiber layer 
      (RNFL) thickness measured with spectral-domain optical coherence tomography 
      (SD-OCT) in different stages of glaucoma. PATIENTS AND METHODS: Thirty normal, 
      150 glaucomatous eyes were included. Glaucomatous eyes were graded into early, 
      moderate and severe stages according to one of the global indices called visual 
      field index (VFI). Complete ophthalmic examination, white on white perimetry and 
      SD-OCT were done for all patients. RNFL thickness of quadrants and average 
      thickness were recorded. Area under receiver operating characteristic curves 
      (AUCs) were used to assess the performance of OCT parameters. RESULTS: AVERAGE, 
      INFERIOR AND SUPERIOR RNFL THICKNESS WERE THE BEST PARAMETERS TO DISCRIMINATE 
      NORMAL FROM EARLY GLAUCOMA (AUC: 0.91-86), early from moderate (AUC: 0.77-0.70) 
      and moderate from severe (AUC: 0.85-83). Average RNFL loss was 18% in early 
      glaucoma, 28% in moderate glaucoma and 41% in severe glaucoma. Early damage tends 
      to be focal and in the lower quadrant. A significant correlation was detected 
      between mean VFI and mean RNFL loss. Glaucoma was restaged according to average 
      RNFL loss into early: ⩾97.5 mu, moderate: <97.5-72.5 mu and severe: <72.5 mu. 
      CONCLUSION: RNFL thickness measured with SD-OCT could discriminate the three 
      stages of glaucoma. RNFL loss can be correlated to visual field loss. Future 
      OCT-based staging of glaucoma, adjunctive to perimetry is possible.
FAU - Elbendary, Amal M
AU  - Elbendary AM
AD  - Mansoura Ophthalmic Center, Mansoura University, Egypt.
FAU - Mohamed Helal, Randa
AU  - Mohamed Helal R
LA  - eng
PT  - Journal Article
DEP - 20121011
PL  - India
TA  - Saudi J Ophthalmol
JT  - Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological 
      Society
JID - 9425601
PMC - PMC3729516
OTO - NOTNLM
OT  - Discrimination
OT  - Glaucoma
OT  - Optical coherence tomography
OT  - Perimetry
OT  - Stages
EDAT- 2013/08/22 06:00
MHDA- 2013/08/22 06:01
PMCR- 2012/10/11
CRDT- 2013/08/22 06:00
PHST- 2012/03/18 00:00 [received]
PHST- 2012/07/07 00:00 [revised]
PHST- 2012/09/30 00:00 [accepted]
PHST- 2013/08/22 06:00 [entrez]
PHST- 2013/08/22 06:00 [pubmed]
PHST- 2013/08/22 06:01 [medline]
PHST- 2012/10/11 00:00 [pmc-release]
AID - SJOPT196 [pii]
AID - 10.1016/j.sjopt.2012.09.001 [doi]
PST - ppublish
SO  - Saudi J Ophthalmol. 2013 Jan;27(1):19-24. doi: 10.1016/j.sjopt.2012.09.001. Epub 
      2012 Oct 11.