PMID- 23964295
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130821
LR  - 20211021
IS  - 1738-5520 (Print)
IS  - 1738-5555 (Electronic)
IS  - 1738-5520 (Linking)
VI  - 43
IP  - 7
DP  - 2013 Jul
TI  - Cardiac rehabilitation increases exercise capacity with a reduction of oxidative 
      stress.
PG  - 481-7
LID - 10.4070/kcj.2013.43.7.481 [doi]
AB  - BACKGROUND AND OBJECTIVES: Reactive oxygen species (ROS) mediate various 
      signaling pathways that underlie vascular inflammation in atherogenesis and 
      cardiovascular diseases. Cardiac rehabilitation (CR) has a variety of multiple 
      beneficial effects, including anti-inflammatory effects. The purpose of the 
      present study was to investigate the effects of CR on ROS in patients with 
      cardiovascular diseases. SUBJECTS AND METHODS: The serum level of derivatives of 
      reactive oxidative metabolites, an index of oxidative stress, was measured in 100 
      patients with cardiovascular diseases before, and, subsequently, 3 and 6 months 
      after, CR. A biological antioxidant potential (BAP) test was applied to assess 
      the antioxidant power of the serum. RESULTS: The resting reactive oxidative 
      metabolite levels decreased 3-6 months after CR pre: 351+/-97 Carratelli unit 
      (CARR U), 3 months: 329+/-77 CARR U, 6 months: 325+/-63 CARR U, all p<0.01 with the 
      increase of the percentage of the predicted values of V̇O2 peak and the 
      percentage of the predicted values of V̇O2 at the anaerobic threshold (V̇O2 AT) 
      and the decrease of the B-type natriuretic peptide (BNP). The BAP test and 
      antioxidative/oxidative stress ratio increased 6 months after CR. The % changes 
      of the antioxidative/oxidative stress ratio was positively correlated with the % 
      changes of V̇O2 AT, and negatively correlated with the % changes of the BNP. 
      CONCLUSION: These results suggest that intensive supervised CR significantly 
      improved exercise capacity, which may be attributable to an adaptive response 
      involving more efficient oxidative metabolites or the increased capacity of 
      endogenous anti-oxidative systems in patients with cardiovascular diseases.
FAU - Fukuda, Taira
AU  - Fukuda T
AD  - Health Center, Hitotsubashi University, Tokyo, Japan. ; Department of Ischemic 
      Circulatory Physiology, University of Tokyo, Tokyo, Japan.
FAU - Kurano, Miwa
AU  - Kurano M
FAU - Fukumura, Kazuya
AU  - Fukumura K
FAU - Yasuda, Tomohiro
AU  - Yasuda T
FAU - Iida, Haruko
AU  - Iida H
FAU - Morita, Toshihiro
AU  - Morita T
FAU - Yamamoto, Yumiko
AU  - Yamamoto Y
FAU - Takano, Nami
AU  - Takano N
FAU - Komuro, Issei
AU  - Komuro I
FAU - Nakajima, Toshiaki
AU  - Nakajima T
LA  - eng
PT  - Journal Article
DEP - 20130731
PL  - Korea (South)
TA  - Korean Circ J
JT  - Korean circulation journal
JID - 101247141
PMC - PMC3744736
OTO - NOTNLM
OT  - Antioxidants
OT  - Cardiovascular diseases
OT  - Exercise therapy
OT  - Oxygen consumption
OT  - Reactive oxygen species
COIS- The authors have no financial conflicts of interest.
EDAT- 2013/08/22 06:00
MHDA- 2013/08/22 06:01
PMCR- 2013/07/01
CRDT- 2013/08/22 06:00
PHST- 2013/04/26 00:00 [received]
PHST- 2013/06/14 00:00 [revised]
PHST- 2013/06/28 00:00 [accepted]
PHST- 2013/08/22 06:00 [entrez]
PHST- 2013/08/22 06:00 [pubmed]
PHST- 2013/08/22 06:01 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - 10.4070/kcj.2013.43.7.481 [doi]
PST - ppublish
SO  - Korean Circ J. 2013 Jul;43(7):481-7. doi: 10.4070/kcj.2013.43.7.481. Epub 2013 
      Jul 31.