PMID- 23964446
OWN - NLM
STAT- MEDLINE
DCOM- 20130924
LR  - 20151119
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 95 Suppl 1
DP  - 2012 Jan
TI  - Do NSAIDs inhibit growth of precancerous cervical cells in vitro?
PG  - S65-73
AB  - BACKGROUND: Cervical cancer is one of the most common cancers worldwide. A 
      promising, novel strategy for cancer treatment is chemoprevention. Non-steroidal 
      anti-inflammatory drugs (NSAIDs) have chemopreventive effects on several cancers 
      including those of cervix. There are few clinical trials of the effects of NSAIDs 
      on precancerous cervical lesions but data from in vitro studies are lacking. 
      OBJECTIVE: To study growth inhibitory effects of nonselective and selective 
      NSAIDs on immortalized cervical cells in vitro. MATERIAL AND METHOD: Cytotoxicity 
      of ibuprofen and celecoxib on immortalized cervical cells was analyzed by Cell 
      Proliferation (MTT) Assay. Propidium Iodide (PI) Assay was used to analyze 
      apoptotic cell death. RESULTS: Ibuprofen and celecoxib had significant growth 
      inhibitory effects with IC50 of 3.00 +/- 0.44 mM and 30. 00 +/- 11.00 uM, 
      respectively. Both drugs significantly induced apoptosis. CONCLUSION: Ibuprofen 
      and celecoxib can inhibit growth and induce apoptotic cell death in immortalized 
      cervical cells. results from the present study highlight the need for further in 
      vivo researches and clinical trials in search of novel strategies for cervical 
      cancer prevention.
FAU - Sakonlaya, Dussadee
AU  - Sakonlaya D
AD  - Department of Clinical Sciences, Faculty of Medicine, Thammasat University, 
      Pathumthani, Thailand. dsmedtu@yahoo.com
FAU - Tapanadechopone, Pirath
AU  - Tapanadechopone P
FAU - Poomkokruk, Auragun
AU  - Poomkokruk A
FAU - Charoenvilaisiri, Saengsoon
AU  - Charoenvilaisiri S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Pyrazoles)
RN  - 0 (Sulfonamides)
RN  - JCX84Q7J1L (Celecoxib)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Anticarcinogenic Agents/*pharmacology
MH  - Apoptosis/*drug effects
MH  - Celecoxib
MH  - Cell Line
MH  - Cell Proliferation/drug effects
MH  - Cervix Uteri/cytology
MH  - Drug Screening Assays, Antitumor
MH  - Female
MH  - Humans
MH  - Ibuprofen/pharmacology
MH  - Precancerous Conditions/*drug therapy
MH  - Pyrazoles/pharmacology
MH  - Sulfonamides/pharmacology
MH  - Uterine Cervical Neoplasms/*drug therapy
EDAT- 2012/01/01 00:00
MHDA- 2013/09/26 06:00
CRDT- 2013/08/23 06:00
PHST- 2013/08/23 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2012 Jan;95 Suppl 1:S65-73.