PMID- 23964818
OWN - NLM
STAT- MEDLINE
DCOM- 20140513
LR  - 20130916
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 133
IP  - 10
DP  - 2013 Oct
TI  - Prognostic significance of immunoglobulin M overexpression in laryngeal squamous 
      cell carcinoma.
PG  - 1080-7
LID - 10.3109/00016489.2013.799776 [doi]
AB  - CONCLUSIONS: Immunoglobulin (Ig) M is overexpressed in laryngeal squamous cell 
      carcinoma (LSCC), and its expression has an independent protective impact on 
      disease-free survival in LSCC. OBJECTIVE: A number of studies have reported on 
      the ectopic expression of Ig in cancer cells, yet there has been a lack of 
      understanding of its clinical and prognostic significance. This study aimed to 
      investigate the expression of IgM in resected specimens of LSCC and to evaluate 
      its clinical significance and prognostic value. METHODS: Immunohistochemistry 
      (IHC) and Western blotting were used to detect the expression of IgM in LSCC and 
      normal laryngeal tissues. The serum level of IgM was also analyzed by 
      immunoturbidimetric assay. RESULTS: IHC and Western blot studies demonstrated 
      that IgM was overexpressed in LSCC specimens (p < 0.001), while the serum level 
      of IgM in patients with LSCC was not different from healthy controls. Chi-squared 
      analysis revealed that the expression level of IgM was negatively correlated with 
      regional lymph node metastasis and tumor stage (p = 0.011 and 0.025, 
      respectively). Univariate analysis showed that IgM expression was significantly 
      correlated with enhanced disease-free survival (DFS) (p = 0.004). In multivariate 
      analysis, IgM retained its independent prognostic value for DFS (p = 0.048, HR = 
      0.506, 95% CI = 0.257-0.995).
FAU - Wang, Haiyang
AU  - Wang H
AD  - Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Luzhou 
      Medical College , Luzhou, P.R. China.
FAU - Cao, Xu
AU  - Cao X
FAU - Liu, Eric-Chen
AU  - Liu EC
FAU - He, Dan
AU  - He D
FAU - Ma, Ying
AU  - Ma Y
FAU - Zhang, Ting
AU  - Zhang T
FAU - Feng, Yang
AU  - Feng Y
FAU - Qin, Gang
AU  - Qin G
LA  - eng
PT  - Journal Article
DEP - 20130822
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blotting, Western
MH  - Carcinoma, Squamous Cell/*blood/mortality/pathology
MH  - China/epidemiology
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Immunoglobulin M/*biosynthesis/blood
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*blood/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Prognosis
MH  - Survival Rate/trends
EDAT- 2013/08/24 06:00
MHDA- 2014/05/14 06:00
CRDT- 2013/08/23 06:00
PHST- 2013/08/23 06:00 [entrez]
PHST- 2013/08/24 06:00 [pubmed]
PHST- 2014/05/14 06:00 [medline]
AID - 10.3109/00016489.2013.799776 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2013 Oct;133(10):1080-7. doi: 10.3109/00016489.2013.799776. 
      Epub 2013 Aug 22.