PMID- 23964960
OWN - NLM
STAT- MEDLINE
DCOM- 20140506
LR  - 20211021
IS  - 1530-6992 (Electronic)
IS  - 1530-6984 (Print)
IS  - 1530-6984 (Linking)
VI  - 13
IP  - 9
DP  - 2013 Sep 11
TI  - Biodegradable mesostructured polymer membranes.
PG  - 4410-5
LID - 10.1021/nl402251x [doi]
AB  - The extracellular matrix (ECM) has a quasi-ordered reticular mesostructure with 
      feature sizes on the order of tenths of to a few hundred nanometers. Approaches 
      to preparing biodegradable synthetic scaffolds for engineered tissues that have 
      the critical mesostructure to mimic ECM are few. Here we present a simple and 
      general solvent evaporation-induced self-assembly (EISA) approach to preparing 
      concentrically reticular mesostructured polyol-polyester membranes. The 
      mesostructures were formed by a novel self-assembly process without covalent or 
      electrostatic interactions, which yielded feature sizes matching those of ECM. 
      The mesostructured materials were nonionic, hydrophilic, and water-permeable and 
      could be shaped into arbitrary geometries such as conformally molded tubular sacs 
      and micropatterned meshes. Importantly, the mesostructured polymers were 
      biodegradable and were used as ultrathin temporary substrates for engineering 
      vascular tissue constructs.
FAU - Tian, Bozhi
AU  - Tian B
AD  - Department of Anesthesiology, Division of Critical Care Medicine, Children's 
      Hospital Boston, Harvard Medical School , Boston, Massachusetts 02115, United 
      States.
FAU - Shankarappa, Sahadev A
AU  - Shankarappa SA
FAU - Chang, Homer H
AU  - Chang HH
FAU - Tong, Rong
AU  - Tong R
FAU - Kohane, Daniel S
AU  - Kohane DS
LA  - eng
GR  - R01 GM073626/GM/NIGMS NIH HHS/United States
GR  - GM073626/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130821
PL  - United States
TA  - Nano Lett
JT  - Nano letters
JID - 101088070
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polymers)
RN  - 0 (polyol)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Biocompatible Materials/chemistry
MH  - Extracellular Matrix/*chemistry
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Polymers/*chemistry
MH  - *Tissue Engineering
MH  - Water/chemistry
PMC - PMC3799971
MID - NIHMS518038
EDAT- 2013/08/24 06:00
MHDA- 2014/05/07 06:00
PMCR- 2014/09/11
CRDT- 2013/08/23 06:00
PHST- 2013/08/23 06:00 [entrez]
PHST- 2013/08/24 06:00 [pubmed]
PHST- 2014/05/07 06:00 [medline]
PHST- 2014/09/11 00:00 [pmc-release]
AID - 10.1021/nl402251x [doi]
PST - ppublish
SO  - Nano Lett. 2013 Sep 11;13(9):4410-5. doi: 10.1021/nl402251x. Epub 2013 Aug 21.