PMID- 23965975
OWN - NLM
STAT- MEDLINE
DCOM- 20140318
LR  - 20211021
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 14
IP  - 8
DP  - 2013 Aug 19
TI  - NF90 in posttranscriptional gene regulation and microRNA biogenesis.
PG  - 17111-21
LID - 10.3390/ijms140817111 [doi]
AB  - Gene expression patterns are effectively regulated by turnover and translation 
      regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene 
      expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA 
      cytoplasmic export, turnover, storage, and translation. Double-stranded RNA 
      binding proteins (DSRBPs) are known to regulate many processes of cellular 
      metabolism, including transcriptional control, translational control, mRNA 
      processing and localization. Nuclear factor 90 (NF90), one of the DSRBPs, is 
      abundantly expressed in vertebrate tissue and participates in many aspects of RNA 
      metabolism. NF90 was originally purified as a component of a DNA binding complex 
      which binds to the antigen recognition response element 2 in the interleukin 2 
      promoter. Recent studies have provided us with interesting insights into its 
      possible physiological roles in RNA metabolism, including transcription, 
      degradation, and translation. In addition, it was shown that NF90 regulates 
      microRNA expression. In this review, we try to focus on the function of NF90 in 
      posttranscriptional gene regulation and microRNA biogenesis.
FAU - Masuda, Kiyoshi
AU  - Masuda K
AD  - Department of Human Genetics and Public Health, Institute of Health Biosciences, 
      the University of Tokushima Graduate School, Tokushima 770-8503, Japan. 
      kiyoshim@tokushima-u.ac.jp
FAU - Kuwano, Yuki
AU  - Kuwano Y
FAU - Nishida, Kensei
AU  - Nishida K
FAU - Rokutan, Kazuhito
AU  - Rokutan K
FAU - Imoto, Issei
AU  - Imoto I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130819
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (ILF3 protein, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Nuclear Factor 90 Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - MicroRNAs/*biosynthesis/genetics
MH  - Neoplasms/genetics/metabolism
MH  - Nuclear Factor 90 Proteins/*physiology
MH  - Protein Biosynthesis
MH  - *RNA Interference
MH  - RNA Stability
MH  - RNA, Messenger/genetics/metabolism
PMC - PMC3759954
EDAT- 2013/08/24 06:00
MHDA- 2014/03/19 06:00
PMCR- 2013/08/01
CRDT- 2013/08/23 06:00
PHST- 2013/07/01 00:00 [received]
PHST- 2013/08/05 00:00 [revised]
PHST- 2013/08/07 00:00 [accepted]
PHST- 2013/08/23 06:00 [entrez]
PHST- 2013/08/24 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - ijms140817111 [pii]
AID - ijms-14-17111 [pii]
AID - 10.3390/ijms140817111 [doi]
PST - epublish
SO  - Int J Mol Sci. 2013 Aug 19;14(8):17111-21. doi: 10.3390/ijms140817111.