PMID- 23966272
OWN - NLM
STAT- MEDLINE
DCOM- 20140317
LR  - 20211021
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 43
IP  - 12
DP  - 2013 Dec
TI  - Dendritic cell subsets in the intestinal lamina propria: ontogeny and function.
PG  - 3098-107
LID - 10.1002/eji.201343740 [doi]
AB  - The intestinal mucosa is exposed to large amounts of foreign antigen (Ag) derived 
      from commensal bacteria, dietary Ags, and intestinal pathogens. Dendritic cells 
      (DCs) are believed to be involved in the induction of tolerance to harmless Ags 
      and in mounting protective immune responses to pathogens and, as such, to play 
      key roles in regulating intestinal immune homeostasis. The characterization of 
      classical DCs (cDCs) in the intestinal lamina propria has been under intense 
      investigation in recent years but the use of markers (including CD11c, CD11b, MHC 
      class II), which are also expressed by intestinal MPhis, has led to some 
      controversy regarding their definition. Here we review recent studies that help 
      to distinguish cDCs subsets from monocyte-derived cells in the intestinal mucosa. 
      We address the phenotype and ontogeny of these cDC subsets and highlight recent 
      findings indicating that these subsets play distinct roles in the regulation of 
      mucosal immune responses in vivo.
CI  - (c) 2013 The Authors. European Journal of Immunology published by Wiley-VCH Verlag 
      GmbH & Co. KGaA Weinheim.
FAU - Persson, Emma K
AU  - Persson EK
AD  - Immunology Section, Department of Experimental Medical Science, Lund University, 
      Lund, Sweden.
FAU - Scott, Charlotte L
AU  - Scott CL
FAU - Mowat, Allan McI
AU  - Mowat AM
FAU - Agace, William W
AU  - Agace WW
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130821
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antigens)
RN  - 0 (Antigens, Differentiation)
SB  - IM
MH  - Animals
MH  - Antigens/immunology
MH  - Antigens, Differentiation/*immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Immune Tolerance/physiology
MH  - Immunity, Mucosal/*physiology
MH  - Macrophages/cytology/*immunology
MH  - Monocytes/cytology/*immunology
MH  - Mucous Membrane/cytology/*immunology
PMC - PMC3933733
OTO - NOTNLM
OT  - Antigen tolerance
OT  - Dendritic cells
OT  - Intestine
OT  - Lamina propria
OT  - Mucosa
EDAT- 2013/08/24 06:00
MHDA- 2014/03/19 06:00
CRDT- 2013/08/23 06:00
PHST- 2013/05/27 00:00 [received]
PHST- 2013/07/02 00:00 [revised]
PHST- 2013/07/09 00:00 [accepted]
PHST- 2013/08/23 06:00 [entrez]
PHST- 2013/08/24 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
AID - 10.1002/eji.201343740 [doi]
PST - ppublish
SO  - Eur J Immunol. 2013 Dec;43(12):3098-107. doi: 10.1002/eji.201343740. Epub 2013 
      Aug 21.