PMID- 23966420
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20210202
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 122
IP  - 14
DP  - 2013 Oct 3
TI  - Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 
      mimetic in mice.
PG  - 2402-11
LID - 10.1182/blood-2013-01-478651 [doi]
AB  - Caloric restriction (CR) is proposed to decrease tumorigenesis through a variety 
      of mechanisms including effects on glycolysis. However, the understanding of how 
      CR affects the response to cancer therapy is still rudimentary. Here, using the 
      Emicro-Myc transgenic mouse model of B-cell lymphoma, we report that by reducing 
      protein translation, CR can reduce expression of the prosurvival Bcl-2 family 
      member Mcl-1 and sensitize lymphomas to ABT-737-induced death in vivo. By using 
      Emicro-Myc lymphoma cells lacking p53, we showed that CR mimetics such as 
      2-deoxyglucose led to a decrease in Mcl-1 expression and sensitized lymphoma 
      cells to ABT-737-induced death independently of p53. In keeping with this, Emicro-Myc 
      lymphoma cells lacking the BH3-only proapoptotic members Noxa, Puma, or Bim were 
      also sensitized by CR mimetics to ABT-737-induced death. Remarkably, neither the 
      loss of both Puma and Noxa, the loss of both Puma and Bim, nor the loss of all 
      three BH3-only proteins prevented sensitization to ABT-737 induced by CR 
      mimetics. Thus, CR can influence Mcl-1 expression and sensitize cells to BH3 
      mimetic-induced apoptosis, independently of the main BH3-only proteins and of 
      p53. Exploiting this may improve the efficiency of, or prevent resistance to, 
      cancer therapy.
FAU - Meynet, Ophelie
AU  - Meynet O
AD  - Centre Mediterraneen de Medecine Moleculaire (C3M), equipe "controle metabolique 
      des morts cellulaires," Institut national de la sante et de la recherche medicale 
      (Inserm) U1065, Nice, France;
FAU - Zunino, Barbara
AU  - Zunino B
FAU - Happo, Lina
AU  - Happo L
FAU - Pradelli, Ludivine A
AU  - Pradelli LA
FAU - Chiche, Johanna
AU  - Chiche J
FAU - Jacquin, Marie A
AU  - Jacquin MA
FAU - Mondragon, Laura
AU  - Mondragon L
FAU - Tanti, Jean-Francois
AU  - Tanti JF
FAU - Taillan, Bruno
AU  - Taillan B
FAU - Garnier, Georges
AU  - Garnier G
FAU - Reverso-Meinietti, Julie
AU  - Reverso-Meinietti J
FAU - Mounier, Nicolas
AU  - Mounier N
FAU - Michiels, Jean-Francois
AU  - Michiels JF
FAU - Michalak, Ewa M
AU  - Michalak EM
FAU - Carles, Michel
AU  - Carles M
FAU - Scott, Clare L
AU  - Scott CL
FAU - Ricci, Jean-Ehrland
AU  - Ricci JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130821
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (ABT-737)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (BH3 Interacting Domain Death Agonist Protein)
RN  - 0 (Bid protein, mouse)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Mcl1 protein, mouse)
RN  - 0 (Myeloid Cell Leukemia Sequence 1 Protein)
RN  - 0 (Nitrophenols)
RN  - 0 (Piperazines)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Sulfonamides)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Apoptosis/drug effects
MH  - BH3 Interacting Domain Death Agonist Protein/metabolism
MH  - Biphenyl Compounds/pharmacology
MH  - *Caloric Restriction
MH  - Disease Models, Animal
MH  - Drug Resistance, Neoplasm/*physiology
MH  - Lymphoma, B-Cell/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Myeloid Cell Leukemia Sequence 1 Protein
MH  - Nitrophenols/pharmacology
MH  - Piperazines/pharmacology
MH  - Proto-Oncogene Proteins c-bcl-2/*biosynthesis
MH  - Sulfonamides/pharmacology
EDAT- 2013/08/24 06:00
MHDA- 2013/11/19 06:00
CRDT- 2013/08/23 06:00
PHST- 2013/08/23 06:00 [entrez]
PHST- 2013/08/24 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - S0006-4971(20)49955-0 [pii]
AID - 10.1182/blood-2013-01-478651 [doi]
PST - ppublish
SO  - Blood. 2013 Oct 3;122(14):2402-11. doi: 10.1182/blood-2013-01-478651. Epub 2013 
      Aug 21.