PMID- 23966710
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 33
IP  - 34
DP  - 2013 Aug 21
TI  - Reliable sex and strain discrimination in the mouse vomeronasal organ and 
      accessory olfactory bulb.
PG  - 13903-13
LID - 10.1523/JNEUROSCI.0037-13.2013 [doi]
AB  - Animals modulate their courtship and territorial behaviors in response to 
      olfactory cues produced by other animals. In rodents, detecting these cues is the 
      primary role of the accessory olfactory system (AOS). We sought to systematically 
      investigate the natural stimulus coding logic and robustness in neurons of the 
      first two stages of accessory olfactory processing, the vomeronasal organ (VNO) 
      and accessory olfactory bulb (AOB). We show that firing rate responses of just a 
      few well-chosen mouse VNO or AOB neurons can be used to reliably encode both sex 
      and strain of other mice from cues contained in urine. Additionally, we show that 
      this population code can generalize to new concentrations of stimuli and appears 
      to represent stimulus identity in terms of diverging paths in coding space. 
      Together, the results indicate that firing rate code on the temporal order of 
      seconds is sufficient for accurate classification of pheromonal patterns at 
      different concentrations and may be used by AOS neural circuitry to discriminate 
      among naturally occurring urine stimuli.
FAU - Tolokh, Illya I
AU  - Tolokh II
AD  - Department of Anatomy and Neurobiology, Washington University School of Medicine, 
      St. Louis, MO, USA.
FAU - Fu, Xiaoyan
AU  - Fu X
FAU - Holy, Timothy E
AU  - Holy TE
LA  - eng
GR  - R01 NS068409/NS/NINDS NIH HHS/United States
GR  - DC005964/DC/NIDCD NIH HHS/United States
GR  - NS068409/NS/NINDS NIH HHS/United States
GR  - R01 DC005964/DC/NIDCD NIH HHS/United States
GR  - R01 DC010381/DC/NIDCD NIH HHS/United States
GR  - DC010381/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Action Potentials/physiology
MH  - Animals
MH  - Discrimination, Psychological/*physiology
MH  - Female
MH  - Likelihood Functions
MH  - Linear Models
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred CBA
MH  - Neurons/*physiology
MH  - Odorants
MH  - Olfactory Bulb/*cytology/physiology
MH  - Psychophysics
MH  - *Sex Characteristics
MH  - Species Specificity
MH  - Vomeronasal Organ/*cytology/physiology
PMC - PMC3755725
EDAT- 2013/08/24 06:00
MHDA- 2013/10/29 06:00
PMCR- 2014/02/21
CRDT- 2013/08/23 06:00
PHST- 2013/08/23 06:00 [entrez]
PHST- 2013/08/24 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
PHST- 2014/02/21 00:00 [pmc-release]
AID - 33/34/13903 [pii]
AID - 0037-13 [pii]
AID - 10.1523/JNEUROSCI.0037-13.2013 [doi]
PST - ppublish
SO  - J Neurosci. 2013 Aug 21;33(34):13903-13. doi: 10.1523/JNEUROSCI.0037-13.2013.