PMID- 23966807
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130822
LR  - 20220408
IS  - 1179-5514 (Print)
IS  - 1179-5514 (Electronic)
IS  - 1179-5514 (Linking)
VI  - 6
DP  - 2013
TI  - Serum cystatin C and tubular urinary enzymes as biomarkers of renal dysfunction 
      in type 2 diabetes mellitus.
PG  - 7-13
LID - 10.4137/CMED.S12633 [doi]
AB  - Renal tubulointerstitium plays an important role in the development and 
      progression of diabetic nephropathy. The aim of this study was to assess serum 
      cystatin C and 2 renal tubular enzymes, neutrophil gelatinase associated 
      lipocalin (NGAL) and N-acetyl-beta-D-glucosaminidase (NAG), as screening markers 
      for early renal dysfunction in patients with type 2 diabetes mellitus (T2DM). ROC 
      curve analysis showed that urinary NAG is the most sensitive marker of 
      microalbuminuria and early renal damage with sensitivity of 83.3%, while serum 
      cystatin C was the most sensitive and specific marker of macroalbuminuria and 
      damage progress with sensitivity of 70.8% and specificity of 83.3% versus 70.6% 
      and 83.3% for uNGAL; and 64.7% and 66.7% for NAG, respectively. Our data indicate 
      that urinary NAG is the most sensitive marker for early renal damage in diabetic 
      patients. However, for damage progress, serum cystatin C is the most sensitive 
      and specific marker for follow-up and monitoring renal dysfunction.
FAU - Assal, Heba S
AU  - Assal HS
AD  - Department of Internal Medicine, Medical Research Division, National Research 
      Centre, Egypt.
FAU - Tawfeek, Salwa
AU  - Tawfeek S
FAU - Rasheed, Enas A
AU  - Rasheed EA
FAU - El-Lebedy, Dalia
AU  - El-Lebedy D
FAU - Thabet, Eman H
AU  - Thabet EH
LA  - eng
PT  - Journal Article
DEP - 20130731
PL  - United States
TA  - Clin Med Insights Endocrinol Diabetes
JT  - Clinical medicine insights. Endocrinology and diabetes
JID - 101578235
PMC - PMC3738377
OTO - NOTNLM
OT  - N-acetyl-beta-D-glucosaminidase
OT  - cystatin C
OT  - diabetic nephropathy
OT  - neutrophil gelatinase-associated lipocalin
EDAT- 2013/08/24 06:00
MHDA- 2013/08/24 06:01
PMCR- 2013/07/31
CRDT- 2013/08/23 06:00
PHST- 2013/08/23 06:00 [entrez]
PHST- 2013/08/24 06:00 [pubmed]
PHST- 2013/08/24 06:01 [medline]
PHST- 2013/07/31 00:00 [pmc-release]
AID - cmed-6-2013-007 [pii]
AID - 10.4137/CMED.S12633 [doi]
PST - epublish
SO  - Clin Med Insights Endocrinol Diabetes. 2013 Jul 31;6:7-13. doi: 
      10.4137/CMED.S12633. eCollection 2013.