PMID- 23970411
OWN - NLM
STAT- MEDLINE
DCOM- 20140204
LR  - 20130823
IS  - 1535-3699 (Electronic)
IS  - 1535-3699 (Linking)
VI  - 238
IP  - 8
DP  - 2013 Aug 1
TI  - Human umbilical cord mesenchymal stem cells attenuate cisplatin-induced acute and 
      chronic renal injury.
PG  - 960-70
LID - 10.1177/1535370213497176 [doi]
AB  - Mesenchymal stem cell is becoming a promising candidate in acute kidney injury 
      (AKI). We first reported that human umbilical cord mesenchymal stem cells 
      (hucMSCs) could ameliorate renal function in ischemic/reperfusion AKI rats, but 
      the role of hucMSCs in cisplatin-induced acute and chronic injury has been 
      demonstrated. More specifically, it is still unknown whether hucMSCs halt renal 
      interstitial fibrosis. In this study, we investigated the effect of hucMSCs in 
      cisplatin-induced kidney injury and explored the mechanism of action. Blood urea 
      nitrogen (BUN) and creatinine (Cr) analyses showed amelioration of functional 
      parameters in hucMSC-treated rats at early damage. Transplantation with hucMSCs 
      promoted renal cell regeneration, inhibited cell apoptosis, abrogated 
      inflammatory responses and protected mitochondria. Moreover, Masson's trichrome 
      staining demonstrated reduced levels of fibrosis in kidney tissues of 
      hucMSC-treated rats at six and eight weeks after cisplatin injection. These 
      results were corroborated by reduced collagen deposit, the ratio of Bax to Bcl-2 
      and transforming growth factor beta mRNA expression. Furthermore, hucMSCs prevented 
      the epithelial-mesenchymal transition (EMT) in injury renal tissues, leading to 
      the attenuation of chronic renal interstitial fibrosis. Taken together, our 
      findings suggested that hucMSCs could decrease the kidney from development of 
      later renal interstitial fibrosis by amelioration of early AKI.
FAU - Peng, Xiujuan
AU  - Peng X
AD  - Centre for Clinical Laboratory of the Affiliated Hospital, School of Medical 
      Science and Laboratory Medicine, Jiangsu University, Zhenjiang, P. R. China.
FAU - Xu, Huitao
AU  - Xu H
FAU - Zhou, Ying
AU  - Zhou Y
FAU - Wang, Bingying
AU  - Wang B
FAU - Yan, Yongmin
AU  - Yan Y
FAU - Zhang, Xu
AU  - Zhang X
FAU - Wang, Mei
AU  - Wang M
FAU - Gao, Shuo
AU  - Gao S
FAU - Zhu, Wei
AU  - Zhu W
FAU - Xu, Wenrong
AU  - Xu W
FAU - Qian, Hui
AU  - Qian H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - AYI8EX34EU (Creatinine)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Acute Kidney Injury/*chemically induced/pathology/*therapy
MH  - Animals
MH  - Apoptosis/physiology
MH  - Blood Urea Nitrogen
MH  - Cells, Cultured
MH  - Chronic Disease
MH  - Cisplatin/*adverse effects
MH  - Coculture Techniques
MH  - Creatinine/blood
MH  - Disease Models, Animal
MH  - Epithelial-Mesenchymal Transition/physiology
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - Kidney/pathology/physiology
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Regeneration/physiology
MH  - Umbilical Cord/*cytology
OTO - NOTNLM
OT  - Human umbilical cord mesenchymal stem cells
OT  - acute kidney injury
OT  - epithelial-mesenchymal transition
OT  - renal interstitial fibrosis
OT  - transplantation
EDAT- 2013/08/24 06:00
MHDA- 2014/02/05 06:00
CRDT- 2013/08/24 06:00
PHST- 2013/08/24 06:00 [entrez]
PHST- 2013/08/24 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
AID - 238/8/960 [pii]
AID - 10.1177/1535370213497176 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2013 Aug 1;238(8):960-70. doi: 10.1177/1535370213497176.