PMID- 23970447
OWN - NLM
STAT- MEDLINE
DCOM- 20140715
LR  - 20131129
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 32
IP  - 12
DP  - 2013 Dec
TI  - Chunggan extract (CGX), methionine-and choline-deficient (MCD) diet-induced 
      hepatosteatosis and oxidative stress in C57BL/6 mice.
PG  - 1258-69
LID - 10.1177/0960327113485253 [doi]
AB  - In the present study, we aimed to evaluate the hepatoprotective and antioxidant 
      effects of Chunggan extract (CGX) in an animal model of hepatosteatosis. The 
      C57BL/6N mice were fed either methionine- and choline-sufficient (MCS) diet (n = 
      10) or a methionine- and choline-deficient (MCD) diet (n = 50) for 4 weeks, and 
      then they were treated orally with CGX (100 or 200 mg/kg), ursodeoxycholic acid 
      (80 mg/kg, as a positive control), or distilled water (DW, MCS diet group, and 
      MCD diet group) for the final 2 weeks (once per day). The MCD diet induced severe 
      hepatic injury with the typical features of hepatosteatosis in both serum and 
      hepatic tissues. CGX treatment significantly attenuated these alterations in the 
      serum levels including triglyceride (TG), aspartate aminotransferase, alanine 
      aminotransferase, alkaline phosphatase, and total bilirubin. Moreover, CGX also 
      efficiently prevented from the hepatic TG accumulation in the hepatic tissue, 
      evidenced by histopathological findings, compared with the MCD diet. In addition, 
      CGX treatment significantly ameliorated the excessive oxidative stress and 
      antioxidant markers in the serum as well as the hepatic levels of reactive oxygen 
      species, the levels of malondialdehyde, the protein carbonyl, and total 
      antioxidant capacity, and the activities of superoxide dismutase, catalase, 
      glutathione peroxidase, and glutathione reductase. In conclusion, our results 
      indicate the experimental relevance of CGX for potential clinical application in 
      patients with hepatosteatotic disorders and a possible mechanism related to its 
      antioxidant properties.
FAU - Park, H-J
AU  - Park HJ
AD  - 1Department of Liver and Immunology Research Center, Daejeon Oriental Hospital of 
      Oriental Medical College of Daejeon University, Republic of Korea.
FAU - Han, J-M
AU  - Han JM
FAU - Kim, H-G
AU  - Kim HG
FAU - Choi, M-K
AU  - Choi MK
FAU - Lee, J-S
AU  - Lee JS
FAU - Lee, H-W
AU  - Lee HW
FAU - Son, C-G
AU  - Son CG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130822
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Antioxidants)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Triglycerides)
RN  - 0 (chunggan)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - AE28F7PNPL (Methionine)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - GAN16C9B8O (Glutathione)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Alkaline Phosphatase/blood
MH  - Animals
MH  - Antioxidants/pharmacology/*therapeutic use
MH  - Aspartate Aminotransferases/blood
MH  - Bilirubin/blood
MH  - Catalase/metabolism
MH  - Cholesterol/metabolism
MH  - Choline Deficiency
MH  - Diet
MH  - Drugs, Chinese Herbal/pharmacology/*therapeutic use
MH  - Fatty Liver/*drug therapy/metabolism
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Glutathione Reductase/metabolism
MH  - Liver/metabolism
MH  - Male
MH  - Methionine/deficiency
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Superoxide Dismutase/metabolism
MH  - Triglycerides/metabolism
OTO - NOTNLM
OT  - CGX
OT  - hepatosteatosis; nonalcoholic fatty liver disease
OT  - methionine and choline-deficient diet
OT  - oxidative stress
EDAT- 2013/08/24 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/08/24 06:00
PHST- 2013/08/24 06:00 [entrez]
PHST- 2013/08/24 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 0960327113485253 [pii]
AID - 10.1177/0960327113485253 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2013 Dec;32(12):1258-69. doi: 10.1177/0960327113485253. Epub 
      2013 Aug 22.