PMID- 23970647
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20211021
IS  - 1758-1052 (Electronic)
IS  - 0956-4624 (Print)
IS  - 0956-4624 (Linking)
VI  - 25
IP  - 3
DP  - 2014 Mar
TI  - Recurrent giant molluscum contagiosum immune reconstitution inflammatory syndrome 
      (IRIS) after initiation of antiretroviral therapy in an HIV-infected man.
PG  - 235-8
LID - 10.1177/0956462413497702 [doi]
AB  - We describe an HIV-infected South African man who experienced two distinct 
      episodes of disseminated giant molluscum contagiosum immune reconstitution 
      inflammatory syndrome (IRIS) over a six-year period. The first episode of 
      molluscum contagiosum IRIS occurred with rapid virologic suppression following 
      antiretroviral therapy initiation. The second episode occurred during a rapid 
      increase in CD4 cells following stable viral suppression with second-line 
      antiretroviral therapy. His molluscum contagiosum lesions then completely 
      resolved during a reduction in CD4 count, despite maintaining virologic 
      suppression. Nearly one year after the resolution of his giant molluscum 
      contagiosum IRIS lesions, he maintains an undetectable viral load, but his level 
      of immune deficiency has not improved. In the absence of well-controlled 
      therapeutic trials, molluscum contagiosum IRIS presents important management 
      challenges.
FAU - Drain, Paul K
AU  - Drain PK
AD  - Division of Infectious Diseases, Department of Medicine, Massachusetts General 
      Hospital, Harvard Medical School, Boston, USA.
FAU - Mosam, Anisa
AU  - Mosam A
FAU - Gounder, Lilishia
AU  - Gounder L
FAU - Gosnell, Bernadett
AU  - Gosnell B
FAU - Manzini, Thandekile
AU  - Manzini T
FAU - Moosa, Mahomed-Yunus S
AU  - Moosa MY
LA  - eng
GR  - R24 TW007988/TW/FIC NIH HHS/United States
GR  - T32 AI007433/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130719
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
SB  - IM
MH  - AIDS-Related Opportunistic Infections/complications/virology
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - CD4-Positive T-Lymphocytes
MH  - HIV Infections/*drug therapy/immunology/virology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*chemically induced
MH  - Immunocompromised Host
MH  - Male
MH  - Molluscum Contagiosum/chemically induced/*immunology/virology
MH  - Recurrence
MH  - South Africa
MH  - Treatment Outcome
MH  - Viral Load/drug effects
PMC - PMC4000481
MID - NIHMS571802
OTO - NOTNLM
OT  - HIV/AIDS
OT  - IRIS
OT  - Molluscum contagiosum
OT  - South Africa
OT  - antiretroviral therapy
OT  - immune reconstitution inflammatory syndrome
EDAT- 2013/08/24 06:00
MHDA- 2014/04/22 06:00
PMCR- 2015/03/01
CRDT- 2013/08/24 06:00
PHST- 2013/08/24 06:00 [entrez]
PHST- 2013/08/24 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - 0956462413497702 [pii]
AID - 10.1177/0956462413497702 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2014 Mar;25(3):235-8. doi: 10.1177/0956462413497702. Epub 2013 
      Jul 19.