PMID- 23972133
OWN - NLM
STAT- MEDLINE
DCOM- 20150625
LR  - 20191027
IS  - 1481-8043 (Electronic)
IS  - 1481-8035 (Linking)
VI  - 15
IP  - 5
DP  - 2013 Sep
TI  - Does the sedation regimen affect adverse events during procedural sedation and 
      analgesia in injection drug users?
PG  - 279-88
AB  - OBJECTIVES: Injection drug users (IDUs) often undergo procedural sedation and 
      analgesia (PSA) as part of emergency department (ED) treatment. We compared 
      adverse events (AEs) using a variety of sedation regimens. METHODS: This was a 
      retrospective analysis of a PSA safety audit in two urban EDs. Consecutive 
      self-reported IDUs were identified, and structured data describing comorbidities, 
      vital signs, sedation regimens (propofol [P], propofol-fentanyl [PF], 
      fentanyl-midazolam [FM], ketofol [1:1 ketamine:propofol, KF], and 
      ketamine-propofol [KP]) and AEs were collected. The primary outcome was the 
      proportion of patients in each sedation group having an AE; the secondary outcome 
      was the proportion of patients having a cardiovascular or respiratory AE. 
      RESULTS: Data were collected on 276 IDUs (78 P, 82 PF, 65 FM, 25 KF, and 26 KP), 
      and 18 patients had AEs (6.5%, 95% CI 4.0-10.3). The AE rates were 0.0%, 8.5%, 
      9.2%, 12.0%, and 7.6%, respectively, with propofol having a significantly lower 
      rate (Pearson coefficient 14.9, p  =  0.007). The cardiovascular/respiratory AE 
      rates were significantly different as well, with P, KP, and KF having the lowest 
      rates (Pearson coefficient 13.3, p  =  0.01). CONCLUSIONS: For IDU PSA, the 
      overall AE rate was 6.5%, and propofol appeared to have a significantly lower 
      rate.
FAU - Xavier Scheuermeyer, Frank
AU  - Xavier Scheuermeyer F
FAU - Andolfatto, Gary
AU  - Andolfatto G
FAU - Qian, Hong
AU  - Qian H
FAU - Grafstein, Eric
AU  - Grafstein E
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - CJEM
JT  - CJEM
JID - 100893237
SB  - IM
MH  - Adult
MH  - Analgesia/*adverse effects
MH  - Conscious Sedation/*methods
MH  - *Drug Users
MH  - *Emergency Service, Hospital
MH  - Emergency Treatment/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2013/08/27 06:00
MHDA- 2015/06/26 06:00
CRDT- 2013/08/27 06:00
PHST- 2013/08/27 06:00 [entrez]
PHST- 2013/08/27 06:00 [pubmed]
PHST- 2015/06/26 06:00 [medline]
AID - 10.2310/8000.2013.130933 [doi]
PST - ppublish
SO  - CJEM. 2013 Sep;15(5):279-88. doi: 10.2310/8000.2013.130933.