PMID- 23972895 OWN - NLM STAT- MEDLINE DCOM- 20131223 LR - 20220330 IS - 1879-1891 (Electronic) IS - 0002-9394 (Linking) VI - 156 IP - 5 DP - 2013 Nov TI - Macular structure parameters as an automated indicator of paracentral scotoma in early glaucoma. PG - 907-917.e1 LID - S0002-9394(13)00444-3 [pii] LID - 10.1016/j.ajo.2013.06.029 [doi] AB - PURPOSE: To evaluate the predictive ability of macular parameters defined in the significance map created using spectral-domain optical coherence tomography (SD-OCT) for paracentral visual field defects in early glaucoma. DESIGN: Prospective comparative study. METHODS: We studied 78 early-glaucomatous eyes of 78 patients, who underwent SD-OCT and standard automated perimetry 10-2. Macular layer parameters included the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) + inner plexiform layer (IPL), and RNFL + GCL + IPL. The minimal distance between the area with abnormal (P < 1%) thickness and foveal center was defined as the shortest distance. A wider area of an abnormally thinned (<1%) region, within either an inferior or a superior hemicircle with a diameter of 6 mm centered at the fovea, was defined as the macular abnormal area. A circumpapillary RNFL parameter was defined in its 36 sectors. Areas under the receiver operating characteristic curves (ROCs) were calculated to discriminate between eyes with (n = 39) and without (n = 39) paracentral visual field defects in the central 5 degrees. RESULTS: Measurement reproducibility was almost perfect in the macular parameters at P < 1% (intraclass correlation, 0.907-0.942). Areas under the ROC were significantly higher (P /=90%, the shortest distance of GCL + IPL (area under the ROC = 0.874) and the macular abnormal area of RNFL (area under the ROC = 0.894) showed sensitivities greater than 50%. CONCLUSIONS: Macular structural parameters defined on an SD-OCT significance map may be potentially useful predictors of the presence of paracentral scotoma. CI - Copyright (c) 2013 Elsevier Inc. All rights reserved. FAU - Kimura, Yugo AU - Kimura Y AD - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Hangai, Masanori AU - Hangai M FAU - Matsumoto, Akiko AU - Matsumoto A FAU - Akagi, Tadamichi AU - Akagi T FAU - Ikeda, Hanako O AU - Ikeda HO FAU - Ohkubo, Shinji AU - Ohkubo S FAU - Sugiyama, Kazuhisa AU - Sugiyama K FAU - Iwase, Aiko AU - Iwase A FAU - Araie, Makoto AU - Araie M FAU - Yoshimura, Nagahisa AU - Yoshimura N LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130821 PL - United States TA - Am J Ophthalmol JT - American journal of ophthalmology JID - 0370500 SB - IM MH - Area Under Curve MH - Cross-Sectional Studies MH - Early Diagnosis MH - Female MH - Glaucoma/*diagnosis MH - Humans MH - Intraocular Pressure MH - Male MH - Middle Aged MH - Nerve Fibers/*pathology MH - Optic Disk/*pathology MH - Optic Nerve Diseases/*diagnosis MH - Prospective Studies MH - ROC Curve MH - Retinal Ganglion Cells/*pathology MH - Scotoma/*diagnosis MH - Tomography, Optical Coherence MH - Visual Field Tests MH - *Visual Fields EDAT- 2013/08/27 06:00 MHDA- 2013/12/24 06:00 CRDT- 2013/08/27 06:00 PHST- 2013/01/04 00:00 [received] PHST- 2013/06/18 00:00 [revised] PHST- 2013/06/19 00:00 [accepted] PHST- 2013/08/27 06:00 [entrez] PHST- 2013/08/27 06:00 [pubmed] PHST- 2013/12/24 06:00 [medline] AID - S0002-9394(13)00444-3 [pii] AID - 10.1016/j.ajo.2013.06.029 [doi] PST - ppublish SO - Am J Ophthalmol. 2013 Nov;156(5):907-917.e1. doi: 10.1016/j.ajo.2013.06.029. Epub 2013 Aug 21.