PMID- 23972942
OWN - NLM
STAT- MEDLINE
DCOM- 20140721
LR  - 20151119
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 38
IP  - 12
DP  - 2013 Dec
TI  - Cortisol and testosterone in hair as biological markers of systolic heart 
      failure.
PG  - 2875-82
LID - S0306-4530(13)00265-5 [pii]
LID - 10.1016/j.psyneuen.2013.07.015 [doi]
AB  - BACKGROUND: Congestive heart failure (CHF) is associated with increased stress 
      and alterations in metabolism, favoring catabolism over anabolism. Hormonal 
      profiles of patients with heart failure have been assessed using serum and saliva 
      as matrices, which are only point measurements and do not provide long-term 
      information. Scalp hair is a novel matrix that allows for measurement of hormones 
      over a period of several months. PATIENTS AND METHODS: We aimed to evaluate 
      whether levels of cortisol and testosterone and their ratio (C/T) in hair 
      correlate with severity of heart failure. We conducted a prospective study in 
      ambulatory male patients with a left ventricular ejection fraction (LVEF)</=40%. 
      Hormone levels were measured using immunoassays in the proximal 2 cm of hair 
      (representing approximately two months of systemic hormone exposure). Primary 
      endpoints included the correlation of hair cortisol, testosterone, and C/T levels 
      with the New York Heart Association (NYHA) class, LVEF, exercise capacity and 
      NT-proBNP. RESULTS: The 44 CHF patients had a median hair level (range) of 
      cortisol of 207 (117.7-1277.3)ng/g. Hair cortisol levels correlated positively 
      with NYHA class (r=0.48, p=0.001) and negatively with treadmill stress test 
      performance, (r=-0.37, p<0.05). The hair testosterone was 5.17 (2.39-24.64)ng/g 
      and the C/T ratio was 39.89 (12.98-173.73). No associations were found between 
      hair testosterone and C/T ratio and heart failure severity; however, the C/T 
      ratio was higher in patients who required a CHF-related hospitalization than in 
      patients who did not require this in the year following the inclusion in the 
      study. CONCLUSIONS: Hair cortisol levels correlate with heart failure severity as 
      assessed by the NYHA class and exercise capacity, while hair testosterone and C/T 
      levels do not correlate with heart failure severity.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Pereg, David
AU  - Pereg D
AD  - Division of Cardiology, Meir Medical Center, and Sackler Faculty of Medicine, 
      Tel-Aviv University, Israel.
FAU - Chan, Justin
AU  - Chan J
FAU - Russell, Evan
AU  - Russell E
FAU - Berlin, Tatiana
AU  - Berlin T
FAU - Mosseri, Morris
AU  - Mosseri M
FAU - Seabrook, Jamie A
AU  - Seabrook JA
FAU - Koren, Gideon
AU  - Koren G
FAU - Van Uum, Stan
AU  - Van Uum S
LA  - eng
PT  - Journal Article
DEP - 20130821
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Biomarkers)
RN  - 3XMK78S47O (Testosterone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Aged
MH  - Biomarkers/*analysis
MH  - Echocardiography
MH  - Endpoint Determination
MH  - Exercise Test
MH  - Female
MH  - Hair/*chemistry
MH  - Heart Failure, Systolic/*metabolism/physiopathology
MH  - Humans
MH  - Hydrocortisone/*analysis
MH  - Immunoassay
MH  - Male
MH  - Prognosis
MH  - Stroke Volume
MH  - Testosterone/*analysis
MH  - Ventricular Function, Left/physiology
OTO - NOTNLM
OT  - Cortisol
OT  - Hair analysis
OT  - Heart failure
OT  - Prognosis
OT  - Testosterone
EDAT- 2013/08/27 06:00
MHDA- 2014/07/22 06:00
CRDT- 2013/08/27 06:00
PHST- 2013/05/09 00:00 [received]
PHST- 2013/07/23 00:00 [revised]
PHST- 2013/07/23 00:00 [accepted]
PHST- 2013/08/27 06:00 [entrez]
PHST- 2013/08/27 06:00 [pubmed]
PHST- 2014/07/22 06:00 [medline]
AID - S0306-4530(13)00265-5 [pii]
AID - 10.1016/j.psyneuen.2013.07.015 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2013 Dec;38(12):2875-82. doi: 
      10.1016/j.psyneuen.2013.07.015. Epub 2013 Aug 21.