PMID- 23973363
OWN - NLM
STAT- MEDLINE
DCOM- 20140516
LR  - 20211021
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 214
IP  - 2
DP  - 2013 Nov 30
TI  - Methylphenidate remediates error-preceding activation of the default mode brain 
      regions in cocaine-addicted individuals.
PG  - 116-21
LID - S0925-4927(13)00181-9 [pii]
LID - 10.1016/j.pscychresns.2013.06.009 [doi]
AB  - Many previous studies suggest the potential of psychostimulants in improving 
      cognitive functioning. Our earlier pharmacological brain imaging study showed 
      that intravenous methylphenidate (MPH) improves inhibitory control by altering 
      cortico-striato-thalamic activations in cocaine-dependent (CD) individuals. Here 
      we provide additional evidence for the effects of MPH in restoring cerebral 
      activations during cognitive performance. Ten CD individuals performed a stop 
      signal task (SST) during functional magnetic resonance imaging (fMRI) in two 
      sessions, in which either MPH (0.5mg/kg body weight) or saline was administered 
      intravenously. In the SST, a frequent go signal instructs participants to make a 
      speeded response and a less frequent stop signal instructs them to withhold the 
      response. Our previous work described increased activation of the 
      precuneus/posterior cingulate cortex and ventromedial prefrontal cortex-regions 
      of the default mode network (DMN)-before participants committed a stop error in 
      healthy control but not CD individuals (Bednarski et al., 2011). The current 
      results showed that, compared to saline, MPH restored error-preceding activations 
      of DMN regions in CD individuals. The extent of the changes in precuneus activity 
      was correlated with MPH-elicited increase in systolic blood pressure. These 
      findings suggest that the influence of MPH on cerebral activations may extend 
      beyond cognitive control and provide additional evidence warranting future 
      studies to investigate the neural mechanisms and physiological markers of the 
      efficacy of agonist therapy in cocaine dependence.
CI  - (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Matuskey, David
AU  - Matuskey D
AD  - Department of Psychiatry, Yale University, New Haven, CT 06519, USA.
FAU - Luo, Xi
AU  - Luo X
FAU - Zhang, Sheng
AU  - Zhang S
FAU - Morgan, Peter T
AU  - Morgan PT
FAU - Abdelghany, Osama
AU  - Abdelghany O
FAU - Malison, Robert T
AU  - Malison RT
FAU - Li, Chiang-shan R
AU  - Li CS
LA  - eng
GR  - K02DA026990/DA/NIDA NIH HHS/United States
GR  - R21 DA026998/DA/NIDA NIH HHS/United States
GR  - T32MH019961/MH/NIMH NIH HHS/United States
GR  - T32 MH019961/MH/NIMH NIH HHS/United States
GR  - R03DA022395/DA/NIDA NIH HHS/United States
GR  - K02 DA026990/DA/NIDA NIH HHS/United States
GR  - K24 DA017899/DA/NIDA NIH HHS/United States
GR  - R03 DA022395/DA/NIDA NIH HHS/United States
GR  - UL1 RR024139/RR/NCRR NIH HHS/United States
GR  - K24-DA017899/DA/NIDA NIH HHS/United States
GR  - R01 DA023248/DA/NIDA NIH HHS/United States
GR  - UL1RR024139/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130823
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Central Nervous System Stimulants)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Central Nervous System Stimulants/*therapeutic use
MH  - Cerebral Cortex/blood supply/*drug effects
MH  - Cocaine-Related Disorders/*complications/pathology
MH  - Cognition Disorders/*drug therapy/*etiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Inhibition, Psychological
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Methylphenidate/*therapeutic use
MH  - Middle Aged
MH  - Models, Neurological
MH  - Neural Pathways/drug effects/pathology
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - Photic Stimulation
MH  - Reaction Time/drug effects
PMC - PMC3811038
MID - NIHMS520292
OTO - NOTNLM
OT  - Catecholamine
OT  - Cognitive control
OT  - Default mode network
OT  - Functional magnetic resonance imaging (fMRI)
OT  - Stimulants
EDAT- 2013/08/27 06:00
MHDA- 2014/05/17 06:00
PMCR- 2014/11/30
CRDT- 2013/08/27 06:00
PHST- 2012/08/30 00:00 [received]
PHST- 2013/06/05 00:00 [revised]
PHST- 2013/06/14 00:00 [accepted]
PHST- 2013/08/27 06:00 [entrez]
PHST- 2013/08/27 06:00 [pubmed]
PHST- 2014/05/17 06:00 [medline]
PHST- 2014/11/30 00:00 [pmc-release]
AID - S0925-4927(13)00181-9 [pii]
AID - 10.1016/j.pscychresns.2013.06.009 [doi]
PST - ppublish
SO  - Psychiatry Res. 2013 Nov 30;214(2):116-21. doi: 
      10.1016/j.pscychresns.2013.06.009. Epub 2013 Aug 23.