PMID- 23973495
OWN - NLM
STAT- MEDLINE
DCOM- 20141215
LR  - 20151119
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 62
DP  - 2013 Nov
TI  - Graft polymerization of guar gum with acryl amide irradiated by microwaves for 
      colonic drug delivery.
PG  - 172-9
LID - S0141-8130(13)00442-X [pii]
LID - 10.1016/j.ijbiomac.2013.08.018 [doi]
AB  - This article is aimed to discuss the modification of guar gum through microwave 
      irradiation by varying the time of irradiation. The characterization of the 
      modified products was carried out using FTIR spectroscopic analysis. The FT-IR 
      spectrum of the pure guar gum (GG) sample showed a broad peak at 3298 cm(-1) 
      while the modified GG sample displayed a peak at 1541 cm(-1) which was absent in 
      the crude sample. The X-ray diffraction (XRD) analysis confirmed the increase in 
      crystallinity due to grafting of the sample with polyacrylamide (GG-g-PAM). 
      Scanning electron microscope (SEM) images revealed that granular form of guar gum 
      was changed into fibrillar structure after grafting. Thermo-gravimetric analysis 
      of the modified samples was also carried out and discussed. The role of guar gum 
      as a matrix for controlled release of drug triamcinolone was evaluated. The 
      GG-acrylamide grafted samples presented a correlation between drug release and 
      time of microwave exposure. The results revealed that such modified product has 
      potential applications in colonic drug delivery system.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Shahid, Muhammad
AU  - Shahid M
AD  - Department of Chemistry and Biochemistry, University of Agriculture Faisalabad, 
      Pakistan.
FAU - Bukhari, Shazia Anwer
AU  - Bukhari SA
FAU - Gul, Yousra
AU  - Gul Y
FAU - Munir, Hira
AU  - Munir H
FAU - Anjum, Fozia
AU  - Anjum F
FAU - Zuber, Mohammad
AU  - Zuber M
FAU - Jamil, Tahir
AU  - Jamil T
FAU - Zia, Khalid Mahmood
AU  - Zia KM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130822
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Acrylic Resins)
RN  - 0 (Drug Carriers)
RN  - 0 (Galactans)
RN  - 0 (Mannans)
RN  - 0 (Plant Gums)
RN  - 1ZK20VI6TY (Triamcinolone)
RN  - 9003-05-8 (polyacrylamide)
RN  - E89I1637KE (guar gum)
SB  - IM
MH  - Acrylic Resins/*chemistry
MH  - Colon/*metabolism
MH  - Drug Carriers/*chemistry/pharmacology
MH  - Drug Liberation
MH  - Galactans/*chemistry
MH  - Hemolysis/drug effects
MH  - Humans
MH  - Mannans/*chemistry
MH  - *Microwaves
MH  - Plant Gums/*chemistry
MH  - *Polymerization
MH  - Triamcinolone/chemistry/metabolism
OTO - NOTNLM
OT  - Acryl amide
OT  - Colonic drug delivery
OT  - Guar gum
OT  - Triamcinolone
EDAT- 2013/08/27 06:00
MHDA- 2014/12/17 06:00
CRDT- 2013/08/27 06:00
PHST- 2013/06/16 00:00 [received]
PHST- 2013/07/29 00:00 [revised]
PHST- 2013/08/11 00:00 [accepted]
PHST- 2013/08/27 06:00 [entrez]
PHST- 2013/08/27 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - S0141-8130(13)00442-X [pii]
AID - 10.1016/j.ijbiomac.2013.08.018 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2013 Nov;62:172-9. doi: 10.1016/j.ijbiomac.2013.08.018. Epub 
      2013 Aug 22.