PMID- 23974017
OWN - NLM
STAT- MEDLINE
DCOM- 20140812
LR  - 20131011
IS  - 1768-3254 (Electronic)
IS  - 0223-5234 (Linking)
VI  - 68
DP  - 2013 Oct
TI  - Small azobenzene derivatives active against bacteria and fungi.
PG  - 178-84
LID - S0223-5234(13)00478-9 [pii]
LID - 10.1016/j.ejmech.2013.07.030 [doi]
AB  - ATP synthase and protein kinase (PKs) are prime targets for drug discovery in a 
      variety of diseases. It is well known that numerous stilbenes are capable to 
      interact and inhibit ATP synthase and PKs. This work focuses on a series of 
      azobenzene based molecules having high structural similarity with antimicrobial 
      stilbenes. An investigation was carried out analyzing the potential toxicity of a 
      large set of molecules by means of computational analysis. A small selection of 
      potential low toxic molecules have been therefore synthesized, characterized and 
      finally microbiologically tested. The synthesized compounds show potent 
      bactericidal activity against Gram+ and a fungus, and are capable of inhibiting 
      biofilm formation. Finally, the compounds demonstrated a thermal stability that 
      makes them potential candidates for incorporation in polymer matrix for 
      application as biomedical devices and food packaging.
CI  - Copyright (c) 2013 Elsevier Masson SAS. All rights reserved.
FAU - Piotto, Stefano
AU  - Piotto S
AD  - Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084 
      Fisciano (Salerno), Italy.
FAU - Concilio, Simona
AU  - Concilio S
FAU - Sessa, Lucia
AU  - Sessa L
FAU - Porta, Amalia
AU  - Porta A
FAU - Calabrese, Elena Concetta
AU  - Calabrese EC
FAU - Zanfardino, Anna
AU  - Zanfardino A
FAU - Varcamonti, Mario
AU  - Varcamonti M
FAU - Iannelli, Pio
AU  - Iannelli P
LA  - eng
PT  - Journal Article
DEP - 20130811
PL  - France
TA  - Eur J Med Chem
JT  - European journal of medicinal chemistry
JID - 0420510
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Azo Compounds)
RN  - 0 (Stilbenes)
RN  - F0U1H6UG5C (azobenzene)
SB  - IM
MH  - Anti-Infective Agents/*chemistry/*pharmacology
MH  - Azo Compounds/*chemistry/pharmacology
MH  - Bacteria/*drug effects
MH  - Biofilms/drug effects
MH  - *Computer Simulation
MH  - *Drug Discovery
MH  - Fungi/*drug effects
MH  - Microbial Sensitivity Tests
MH  - Molecular Structure
MH  - Stilbenes/chemistry/pharmacology
MH  - Structure-Activity Relationship
OTO - NOTNLM
OT  - ADMET
OT  - Antimicrobial
OT  - Azobenzenes
EDAT- 2013/08/27 06:00
MHDA- 2014/08/13 06:00
CRDT- 2013/08/27 06:00
PHST- 2013/03/26 00:00 [received]
PHST- 2013/06/11 00:00 [revised]
PHST- 2013/07/18 00:00 [accepted]
PHST- 2013/08/27 06:00 [entrez]
PHST- 2013/08/27 06:00 [pubmed]
PHST- 2014/08/13 06:00 [medline]
AID - S0223-5234(13)00478-9 [pii]
AID - 10.1016/j.ejmech.2013.07.030 [doi]
PST - ppublish
SO  - Eur J Med Chem. 2013 Oct;68:178-84. doi: 10.1016/j.ejmech.2013.07.030. Epub 2013 
      Aug 11.