PMID- 23974055
OWN - NLM
STAT- MEDLINE
DCOM- 20140718
LR  - 20131126
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 74
IP  - 12
DP  - 2013 Dec
TI  - Profile of human leukocyte antigen class I alleles in patients with dengue 
      infection from Western India.
PG  - 1624-8
LID - S0198-8859(13)00229-2 [pii]
LID - 10.1016/j.humimm.2013.08.004 [doi]
AB  - Human leukocyte antigen (HLA) class I alleles are known to affect the cytotoxic T 
      lymphocyte responses and influence susceptibility to viral infections. The 
      objective of the present study was to find out whether HLA class I alleles are 
      associated with clinical manifestations of dengue virus infection. The profile of 
      HLA class I alleles were investigated in 224 human subjects [85 dengue fever (DF) 
      cases, 29 dengue hemorrhagic fever (DHF) cases and 110 healthy controls (HCs)] 
      from Western India using PCR based methods. Results revealed significantly higher 
      frequency of HLA-A( *)33 in DF cases compared to HCs [P = 0.032, Odds ratio (OR) 
      2.12]. The frequency of HLA-A( *)02:11 was higher in DHF cases compared to DF 
      cases. The frequency of HLA-B( *)18 was significantly higher in dengue (DEN) cases 
      [P = 0.047 Pc = 0.846, OR 3.53]. The frequency of HLA-Cw( *)07 allele was 
      significantly higher in DEN cases [DEN vs. HCs: P = 0.0120, Pc = 0.168, OR 2.00]. 
      Significance was observed even when the cases were categorized in to DF and DHF 
      [DF vs. HCs: P = 0.0349, Pc = 0.49, OR 1.87; DHF vs. HCs: P = 0.0399, Pc = 0.56, 
      OR 2.4]. The combined frequency of HLA-Cw( *)07 with HLA-DRB1( *)07/( *)15 genotype 
      was significantly higher in DHF cases as compared to DF and HCs [DHF vs. HCs: P = 
      0.022, OR 5.31; DHF vs. DF: P = 0.027, OR 5.49]. On the other hand, the frequency 
      of combination of HLA-Cw( *)07 without HLA-DRB1( *)07 was significantly higher in 
      DF cases compared to HCs [DF vs. HCs: P = 0.002, OR 2.42 (1.28-4.55)]. The 
      results suggest that HLA-A( * *)33 may be associated with DF while HLA-B( *)18 and 
      HLA-Cw( *)07 alleles may be associated with symptomatic dengue requiring 
      hospitalization. In the presence of HLA-DRB1( *)07/( *)15 genotype, HLA-Cw( *)07 is 
      associated with increased risk of developing DHF while in the presence of other 
      HLA-DRB1 alleles, HLA-Cw( *)07 is associated with DF.
CI  - Copyright (c) 2013 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Alagarasu, K
AU  - Alagarasu K
AD  - Dengue Group, National Institute of Virology, 20 A, Dr. Ambedkar Road, Pune 
      411001, Maharashtra, India. Electronic address: alagarasu@gmail.com.
FAU - Mulay, A P
AU  - Mulay AP
FAU - Sarikhani, M
AU  - Sarikhani M
FAU - Rashmika, D
AU  - Rashmika D
FAU - Shah, P S
AU  - Shah PS
FAU - Cecilia, D
AU  - Cecilia D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130820
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Alleles
MH  - Case-Control Studies
MH  - Dengue/*genetics/immunology
MH  - Dengue Virus/immunology
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-A Antigens/genetics/immunology
MH  - HLA-B Antigens/genetics/immunology
MH  - HLA-C Antigens/genetics/immunology
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Humans
MH  - India
MH  - Male
MH  - Young Adult
EDAT- 2013/08/27 06:00
MHDA- 2014/07/19 06:00
CRDT- 2013/08/27 06:00
PHST- 2013/04/19 00:00 [received]
PHST- 2013/07/01 00:00 [revised]
PHST- 2013/08/10 00:00 [accepted]
PHST- 2013/08/27 06:00 [entrez]
PHST- 2013/08/27 06:00 [pubmed]
PHST- 2014/07/19 06:00 [medline]
AID - S0198-8859(13)00229-2 [pii]
AID - 10.1016/j.humimm.2013.08.004 [doi]
PST - ppublish
SO  - Hum Immunol. 2013 Dec;74(12):1624-8. doi: 10.1016/j.humimm.2013.08.004. Epub 2013 
      Aug 20.