PMID- 23975041
OWN - NLM
STAT- MEDLINE
DCOM- 20140611
LR  - 20181202
IS  - 1361-6528 (Electronic)
IS  - 0957-4484 (Linking)
VI  - 24
IP  - 37
DP  - 2013 Sep 20
TI  - Nanostructured hydroxyapatite/poly(lactic-co-glycolic acid) composite coating for 
      controlling magnesium degradation in simulated body fluid.
PG  - 375103
LID - 10.1088/0957-4484/24/37/375103 [doi]
AB  - Biodegradable magnesium (Mg) and its alloys have many attractive properties 
      (e.g. comparable mechanical properties to cortical bone) for orthopedic implant 
      applications, but they degrade too rapidly in the human body to meet clinical 
      requirements. Nanostructured hydroxyapatite (nHA)/poly(lactic-co-glycolic acid) 
      (PLGA) composite coatings provide synergistic properties for controlling 
      degradation of Mg-based substrates and improving bone-implant integration. In 
      this study, nHA/PLGA composites were spin coated onto Mg-based substrates and the 
      results showed that the nHA/PLGA coatings retained nano-scale features with nHA 
      dispersed in PLGA matrix. In comparison with non-coated Mg, the nHA/PLGA 
      composite coated Mg increased the corrosion potential and decreased the corrosion 
      current in revised simulated body fluid (rSBF). After 24 h of immersion in rSBF, 
      increased calcium phosphate (CaP) deposition and formation of Mg-substituted CaP 
      rosettes were observed on the surface of the nHA/PLGA coated Mg, indicating 
      greater bioactivity. In contrast, no significant CaP was deposited on the PLGA 
      coated Mg. Since both PLGA coating and nHA/PLGA coating showed some degree of 
      delamination from Mg-based substrates during extended immersion in rSBF, the 
      coating processing and properties should be further optimized in order to take 
      full advantage of biodegradable Mg and nHA/PLGA nanocomposites for orthopedic 
      applications.
FAU - Johnson, Ian
AU  - Johnson I
AD  - Department of Bioengineering, University of California at Riverside, 900 
      University Avenue, Riverside, CA 92521, USA.
FAU - Akari, Khalid
AU  - Akari K
FAU - Liu, Huinan
AU  - Liu H
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20130823
PL  - England
TA  - Nanotechnology
JT  - Nanotechnology
JID - 101241272
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Ions)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 7YNJ3PO35Z (Hydrogen)
RN  - 91D9GV0Z28 (Durapatite)
RN  - I38ZP9992A (Magnesium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Body Fluids/*chemistry
MH  - Calcium/analysis/chemistry
MH  - Coated Materials, Biocompatible/*chemistry
MH  - Durapatite/*chemistry
MH  - Humans
MH  - Hydrogen/analysis
MH  - Hydrogen-Ion Concentration
MH  - Ions
MH  - Lactic Acid/*chemistry
MH  - Magnesium/analysis/*chemistry
MH  - Molecular Weight
MH  - Nanostructures/*chemistry/ultrastructure
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Surface Properties
EDAT- 2013/08/27 06:00
MHDA- 2014/06/12 06:00
CRDT- 2013/08/27 06:00
PHST- 2013/08/27 06:00 [entrez]
PHST- 2013/08/27 06:00 [pubmed]
PHST- 2014/06/12 06:00 [medline]
AID - 10.1088/0957-4484/24/37/375103 [doi]
PST - ppublish
SO  - Nanotechnology. 2013 Sep 20;24(37):375103. doi: 10.1088/0957-4484/24/37/375103. 
      Epub 2013 Aug 23.