PMID- 23975061
OWN - NLM
STAT- MEDLINE
DCOM- 20150124
LR  - 20220311
IS  - 1573-3688 (Electronic)
IS  - 1053-0487 (Linking)
VI  - 24
IP  - 2
DP  - 2014 Jun
TI  - Matrix metalloproteinase-3, vitamin D receptor gene polymorphisms, and 
      occupational risk factors in lumbar disc degeneration.
PG  - 370-81
LID - 10.1007/s10926-013-9472-7 [doi]
AB  - BACKGROUND: Lumbar disc degeneration (LDD) is a process that begins early in 
      life, contributing to the development of low back pain. LDD is a consequence of a 
      variety of factors, and its etiology remains poorly understood. Objectives to 
      investigate occupational and genetic risk factors inducing lumbar disc 
      degeneration, and to evaluate the possible association of genetic polymorphisms 
      of matrix metalloproteinase 3 (MMP-3) and vitamin D receptor (VDR) with the 
      severity of LDD in an Egyptian population. SUBJECTS AND METHODS: A case control 
      study involving 84 LDD and 60 controls was carried out. Five types of work 
      related factors were investigated by questionnaire, complete neurological 
      examination for all subjects and MRI for the cases. Polymerase chain reaction and 
      restriction fragment length polymorphism methods were applied to detect 
      polymorphisms in MMP-3 Promoter (-1,171 6A/5A) (rs 731236) and VDR-Apa (rs 
      35068180). RESULTS: We found that family history, back injury, smoking, high 
      level of sitting, bending/twisting, physical workload, lifting, whole body 
      vibration, mutant allele 5A of MMP-3 and mutant allele T of VDR were 
      significantly associated with LDD (OR = 2.9, 3.1, 2.1, 11.1, 15.9, 11.7, 8.2, 
      12.6, 2.5 and 3.1 respectively, p < 0.05). Cases that carry allele 5A and/or 
      allele T were associated with LDD severity. CONCLUSION: LDD is closely associated 
      in occurrence and severity with occupational, environmental risk factors and 
      susceptibility genes namely MMP-3, and VDR (ApaI). This study throws light on the 
      importance of screening for early detection of susceptible individuals and 
      disease prevention.
FAU - Zawilla, N H
AU  - Zawilla NH
AD  - Occupational and Environmental Medicine Department, Faculty of Medicine, Cairo 
      University, Giza, Egypt, nerhamdy71@hotmail.com.
FAU - Darweesh, H
AU  - Darweesh H
FAU - Mansour, N
AU  - Mansour N
FAU - Helal, S
AU  - Helal S
FAU - Taha, F M
AU  - Taha FM
FAU - Awadallah, M
AU  - Awadallah M
FAU - El Shazly, R
AU  - El Shazly R
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Occup Rehabil
JT  - Journal of occupational rehabilitation
JID - 9202814
RN  - 0 (Receptors, Calcitriol)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Back Injuries/complications
MH  - Case-Control Studies
MH  - Egypt
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Intervertebral Disc Degeneration/diagnosis/epidemiology/*genetics
MH  - *Lumbar Vertebrae
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Neurologic Examination
MH  - Occupational Diseases/diagnosis/epidemiology/*genetics
MH  - Physical Exertion
MH  - Polymorphism, Restriction Fragment Length
MH  - Posture
MH  - Promoter Regions, Genetic
MH  - Receptors, Calcitriol/*genetics
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Smoking
MH  - Surveys and Questionnaires
MH  - Vibration
EDAT- 2013/08/27 06:00
MHDA- 2015/01/27 06:00
CRDT- 2013/08/27 06:00
PHST- 2013/08/27 06:00 [entrez]
PHST- 2013/08/27 06:00 [pubmed]
PHST- 2015/01/27 06:00 [medline]
AID - 10.1007/s10926-013-9472-7 [doi]
PST - ppublish
SO  - J Occup Rehabil. 2014 Jun;24(2):370-81. doi: 10.1007/s10926-013-9472-7.