PMID- 23975474
OWN - NLM
STAT- MEDLINE
DCOM- 20140407
LR  - 20211021
IS  - 1573-3254 (Electronic)
IS  - 1090-7165 (Linking)
VI  - 18 Suppl 1
DP  - 2014 Jan
TI  - Randomized controlled trial to evaluate the impact of pharmaceutical care on 
      therapeutic success in HIV-infected patients in Southern Brazil.
PG  - S75-84
LID - 10.1007/s10461-013-0596-8 [doi]
AB  - A non-blinded randomized controlled trial evaluated efficacy of pharmaceutical 
      care (PC) (Dader method) on self-reported antiretroviral adherence and 
      undetectable plasma viral load (UPVL), compared with usual care (UC) in 
      HIV-positive patients in Brazil. Most were male (63 %), mean age 40.3 years 
      (SD = 10). After 12 months, 79.8 % of those receiving PC versus 73.8 % in UC were 
      adherent (RR 1.05, 95 % CI 0.95-1.15, P = 0.35), and 50.3 versus 49.8 % (PC vs. 
      UC, respectively) had UPVL (RR 1.08, 95 % CI 0.97-1.20, P = 0.15). Factors 
      associated with self-reported adherence were regular employment, UPVL, no 
      depressive symptoms, and lower pill load in the treatment regimen. Older age, 
      education, CD4 count <200 cells/mm(3), and shorter treatment duration were 
      associated with UPVL. Of 94 reported drug-related problems, 43 % resolved. In 
      subgroup analyses of patients who experienced therapeutic failure and who were 
      non-adherent at the beginning of the trial (N = 50), no differences were found in 
      UPVL (HR 1.35, 95 % CI 0.57-3.19). Only education level (>12 years) was 
      independently predictive of viral suppression (HR 7.47, 95 % CI 1.69-32.91). In 
      conclusion, PC was not associated with increased self-reported adherence to ART 
      or UPVL in patients treated at a health care facility in southern Brazil. The 
      study suggests, however, that PC could be effective for the subgroup of patients 
      with poor adherence.
FAU - Silveira, Marysabel Pinto Telis
AU  - Silveira MP
AD  - Departamento de Fisiologia e Farmacologia, Instituto de Biologia, Universidade 
      Federal de Pelotas (UFPel), Campus Universitario, Capao do Leao, S/N, Caixa 
      Postal 354, Pelotas, Rio Grande do Sul, CEP 96010900, Brazil, 
      marysabelfarmacologia@yahoo.com.br.
FAU - Guttier, Marilia Cruz
AU  - Guttier MC
FAU - Page, Kimberly
AU  - Page K
FAU - Moreira, Leila Beltrami
AU  - Moreira LB
LA  - eng
GR  - P30 MH062246/MH/NIMH NIH HHS/United States
GR  - D43TW000003/TW/FIC NIH HHS/United States
GR  - R25MH064712/MH/NIMH NIH HHS/United States
GR  - D43TW005799/TW/FIC NIH HHS/United States
GR  - P30MH062246/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - AIDS Behav
JT  - AIDS and behavior
JID - 9712133
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-HIV Agents/adverse effects/*therapeutic use
MH  - Brazil
MH  - CD4 Lymphocyte Count
MH  - Female
MH  - HIV Infections/*drug therapy/etiology/virology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - *Medication Adherence
MH  - Middle Aged
MH  - Pharmaceutical Services/organization & administration/*statistics & numerical 
      data
MH  - *Pharmacists
MH  - Professional Role
MH  - Self Report
MH  - Sex Distribution
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Viral Load/drug effects
MH  - Young Adult
EDAT- 2013/08/27 06:00
MHDA- 2014/04/08 06:00
CRDT- 2013/08/27 06:00
PHST- 2013/08/27 06:00 [entrez]
PHST- 2013/08/27 06:00 [pubmed]
PHST- 2014/04/08 06:00 [medline]
AID - 10.1007/s10461-013-0596-8 [doi]
PST - ppublish
SO  - AIDS Behav. 2014 Jan;18 Suppl 1:S75-84. doi: 10.1007/s10461-013-0596-8.