PMID- 23975535
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20220409
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 28
IP  - 4
DP  - 2013 Dec
TI  - Protective effects of N-acetylcysteine on 3, 
      4-methylenedioxymethamphetamine-induced neurotoxicity in male Sprague-Dawley 
      rats.
PG  - 677-86
LID - 10.1007/s11011-013-9423-1 [doi]
AB  - Exposure to 3, 4-methylenedioxymethamphetamine (MDMA) leads to spatial memory 
      impairment and hippocampal cell death. In the present study we have examined the 
      protective effects of N-acetyl-L-cysteine (NAC) on MDMA-induced neurotoxicity. A 
      total of 56 male Sprague Dawley rats (200-250 g) received twice daily 
      intraperitoneal (IP) injections of 5, 10 or 20 mg/kg MDMA plus NAC (100 mg/kg). 
      Rectal temperatures were recorded before and after daily treatment. We used a 
      Morris water maze (MWM) to assess spatial learning and memory. At the end of the 
      study rats' brains were removed, cells were counted and the level of Bcl-2, Bax 
      and caspase-3 expression in the hippocampi were measured. NAC pretreatment 
      significantly reduced MDMA-induced hyperthermia. In the MWM, NAC significantly 
      attenuated the MDMA-induced increase in distance traveled; however the observed 
      increase in escape latency was not significant. The decrease in time spent in the 
      target quadrant in MDMA animals was significantly attenuated (p < 0.001, all 
      groups). NAC protected against MDMA-induced cell death and the up -regulation of 
      Bax and Caspase-3, in addition to the down-regulation of Bcl-2. This data 
      suggested a possible benefit of NAC in the treatment of neurotoxicity among those 
      who use MDMA.
FAU - Soleimani Asl, Sara
AU  - Soleimani Asl S
AD  - Research Center for Behavioral Disorders and Substance Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Mousavizadeh, Kazem
AU  - Mousavizadeh K
FAU - Pourheydar, Bagher
AU  - Pourheydar B
FAU - Soleimani, Mansoureh
AU  - Soleimani M
FAU - Rahbar, Elnaz
AU  - Rahbar E
FAU - Mehdizadeh, Mehdi
AU  - Mehdizadeh M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130824
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 0 (Bax protein, rat)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (bcl-2-Associated X Protein)
RN  - EC 3.4.22.- (Caspase 3)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
EIN - Metab Brain Dis. 2014 Sep;29(3):887. Mousavizedeh, Kazem [Corrected to 
      Mousavizadeh, Kazem]
MH  - Acetylcysteine/pharmacology/*therapeutic use
MH  - Animals
MH  - Caspase 3/metabolism
MH  - Cell Death/*drug effects
MH  - Down-Regulation/drug effects
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Maze Learning/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurotoxicity Syndromes/drug therapy/*prevention & control
MH  - Proto-Oncogene Proteins c-bcl-2/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - bcl-2-Associated X Protein/metabolism
EDAT- 2013/08/27 06:00
MHDA- 2014/06/21 06:00
CRDT- 2013/08/27 06:00
PHST- 2013/03/04 00:00 [received]
PHST- 2013/07/17 00:00 [accepted]
PHST- 2013/08/27 06:00 [entrez]
PHST- 2013/08/27 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
AID - 10.1007/s11011-013-9423-1 [doi]
PST - ppublish
SO  - Metab Brain Dis. 2013 Dec;28(4):677-86. doi: 10.1007/s11011-013-9423-1. Epub 2013 
      Aug 24.