PMID- 23978150
OWN - NLM
STAT- MEDLINE
DCOM- 20140606
LR  - 20220309
IS  - 1939-0084 (Electronic)
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 127
IP  - 5
DP  - 2013 Oct
TI  - Either main or accessory olfactory system signaling can mediate the rewarding 
      effects of estrous female chemosignals in sexually naive male mice.
PG  - 755-62
LID - 10.1037/a0033945 [doi]
AB  - A long-held view has been that interest of male mice in female body odors 
      reflects an activation of reward circuits in the male brain following their 
      detection by the vomeronasal organ (VNO) and processing via the accessory 
      olfactory system. We found that adult, sexually naive male mice acquired a 
      conditioned place preference (CPP) after repeatedly receiving estrous female 
      urine on the nose and being placed in an initially nonpreferred chamber with 
      soiled estrous bedding on the floor. CPP was not acquired in control mice that 
      received saline on the nose before being placed in a nonpreferred chamber with 
      clean bedding. Robust acquisition of a CPP using estrous female odors as the 
      reward persisted in separate groups of mice in which VNO-accessory olfactory 
      function was disrupted by bilateral lesioning of the accessory olfactory bulb 
      (AOB) or in which main olfactory function was disrupted by zinc sulfate lesions 
      of the main olfactory epithelium (MOE). By contrast, no CPP was acquired for 
      estrous odors in males that received combined AOB and MOE lesions. Either the 
      main or the accessory olfactory system suffices to mediate the rewarding effects 
      of estrous female odors in the male mouse, even in the absence of prior mating 
      experience. The main olfactory system is part of the circuitry that responds to 
      chemosignals involved in motivated behavior, a role that may be particularly 
      important for humans who lack a functional accessory olfactory system.
CI  - 2013 APA, all rights reserved
FAU - Korzan, Wayne J
AU  - Korzan WJ
AD  - Department of Biology.
FAU - Freamat, Mihael
AU  - Freamat M
FAU - Johnson, Adam G
AU  - Johnson AG
FAU - Cherry, James A
AU  - Cherry JA
FAU - Baum, Michael J
AU  - Baum MJ
LA  - eng
GR  - R01 DC008962/DC/NIDCD NIH HHS/United States
GR  - DC008962/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130826
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - 0 (Pheromones)
SB  - IM
MH  - Animals
MH  - Conditioning, Psychological
MH  - Estrous Cycle/*physiology/urine
MH  - Female
MH  - Male
MH  - Mice
MH  - Olfactory Pathways/*physiology
MH  - Pheromones/*physiology
MH  - *Reward
PMC - PMC3983571
MID - NIHMS564061
EDAT- 2013/08/28 06:00
MHDA- 2014/06/07 06:00
PMCR- 2014/10/01
CRDT- 2013/08/28 06:00
PHST- 2013/08/28 06:00 [entrez]
PHST- 2013/08/28 06:00 [pubmed]
PHST- 2014/06/07 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - 2013-30440-001 [pii]
AID - 10.1037/a0033945 [doi]
PST - ppublish
SO  - Behav Neurosci. 2013 Oct;127(5):755-62. doi: 10.1037/a0033945. Epub 2013 Aug 26.