PMID- 23978333
OWN - NLM
STAT- MEDLINE
DCOM- 20140724
LR  - 20220408
IS  - 1095-9319 (Electronic)
IS  - 0026-2862 (Linking)
VI  - 90
DP  - 2013 Nov
TI  - Possible involvement of oxidative stress as a causative factor in blood-brain 
      barrier dysfunction in stroke-prone spontaneously hypertensive rats.
PG  - 169-72
LID - S0026-2862(13)00147-7 [pii]
LID - 10.1016/j.mvr.2013.08.005 [doi]
AB  - To elucidate the pathogenic roles of oxidative stress on blood-brain-barrier 
      (BBB) dysfunction, we compared the chronological changes of oxidative stress in 
      blood and cerebral tissue between stroke-prone spontaneously hypertensive rats 
      (SHRSP) and normotensive Wistar-Kyoto rats (WKY). Plasma and tissue oxidative 
      stress was assayed by the diacron-reactive oxygen metabolite (d-ROM) test using 
      8-hydroxy-2'-deoxyguanosine (8-OHdG) as a reference oxidative stress marker. The 
      plasma and cerebral cortex d-ROM levels increased in SHRSP after 16weeks of age, 
      but not in WKY. There were no significant differences in 8-OHdG or lipid 
      peroxidation markers between SHRSP and WKY. Antioxidant capacity, as estimated by 
      the biological antioxidant potential test, was similar between SHRSP and WKY at 
      all ages examined. The changes in plasma and tissue d-ROM levels coincided with 
      changes in glucose transporter-1 and aquaporin-4 expression, as functional 
      constituents of the BBB. These results indicate that plasma oxidative stress 
      increases before the onset of tissue damage, and plays an important role in BBB 
      dysfunction rather than decreases in antioxidant capacity. The plasma d-ROM test 
      appears to be useful for predicting vasogenic cerebral edema in severe 
      hypertension.
CI  - (c) 2013.
FAU - Takemori, Kumiko
AU  - Takemori K
AD  - Department of Food Science and Nutrition, Faculty of Agriculture, Kinki 
      University, Nara, Japan. Electronic address: kuriman@nara.kindai.ac.jp.
FAU - Murakami, Tetsuo
AU  - Murakami T
FAU - Kometani, Takashi
AU  - Kometani T
FAU - Ito, Hiroyuki
AU  - Ito H
LA  - eng
PT  - Journal Article
DEP - 20130824
PL  - United States
TA  - Microvasc Res
JT  - Microvascular research
JID - 0165035
RN  - 0 (Aqp4 protein, rat)
RN  - 0 (Aquaporin 4)
RN  - 0 (Biomarkers)
RN  - 0 (Glucose Transporter Type 1)
RN  - 0 (Slc2a1 protein, rat)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Animals
MH  - Aquaporin 4/metabolism
MH  - Biomarkers/metabolism
MH  - Blood Pressure
MH  - Blood-Brain Barrier/*metabolism/physiopathology
MH  - Body Weight
MH  - Brain Edema/*etiology/metabolism/physiopathology
MH  - *Capillary Permeability
MH  - Deoxyguanosine/analogs & derivatives/metabolism
MH  - Disease Models, Animal
MH  - Glucose Transporter Type 1/metabolism
MH  - Hypertension/*complications/metabolism/physiopathology
MH  - Lipid Peroxidation
MH  - Male
MH  - *Oxidative Stress
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Stroke/*etiology/metabolism/physiopathology
MH  - Time Factors
EDAT- 2013/08/28 06:00
MHDA- 2014/07/25 06:00
CRDT- 2013/08/28 06:00
PHST- 2013/03/28 00:00 [received]
PHST- 2013/06/13 00:00 [revised]
PHST- 2013/08/14 00:00 [accepted]
PHST- 2013/08/28 06:00 [entrez]
PHST- 2013/08/28 06:00 [pubmed]
PHST- 2014/07/25 06:00 [medline]
AID - S0026-2862(13)00147-7 [pii]
AID - 10.1016/j.mvr.2013.08.005 [doi]
PST - ppublish
SO  - Microvasc Res. 2013 Nov;90:169-72. doi: 10.1016/j.mvr.2013.08.005. Epub 2013 Aug 
      24.