PMID- 23980356
OWN - NLM
STAT- MEDLINE
DCOM- 20140925
LR  - 20171116
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 33
IP  - 6
DP  - 2013 Jun
TI  - [Significance of serum MMP-3, TIMP-1, and monocyte CD147 in rheumatoid arthritis 
      patients of damp-heat Bi-syndrome and of cold-damp Bi-syndrome].
PG  - 770-3
AB  - OBJECTIVE: To explore the clinical significance of serum matrix 
      metalloproteinase-3 (MMP-3), tissue inhibitor of metalloproteinase-1 (TIMP-1), 
      and monocyte CD147 in rheumatoid arthritis (RA) patients of damp-heat Bi-syndrome 
      (DHBS) and of cold-damp Bi-syndrome (CDBS). METHODS: The clinical data of 22 
      patients from inpatients and outpatients with RA were collected, and their 
      peripheral blood was withdrawal. The disease activity scores [DAS28(4)] were 
      assessed. The serum levels of MMP-3 and TIMP-1 were detected by double antibody 
      sandwich enzyme linked immunosorbent assay (ELISA). The mean fluorescence 
      intensity (MFI) and the expression percentage of CD147 on CD14+ monocytes were 
      detected by flow cytometry. The difference of each index between RA patients of 
      DHBS and RA patients of CDBS was analyzed. RESULTS: The level of serum MMP-3 and 
      the MFI of CD147 on the monocyte surface were obviously higher in RA patients of 
      DHBS than in those of CDBS and the normal control group (P < 0.05). The 
      concentration of serum TIMP-1 was obviously higher in RA patients of DHBS than in 
      those of the normal control group (P < 0.05), while there was no statistical 
      difference between the two syndrome types. The percentage of CD147 expression was 
      obviously lower in DHBS than in those of CDBS and the normal control group (P < 
      0.05). CONCLUSIONS: Increased serum MMP-3 level of RA patients of DHBS might 
      result in destroy of joint cartilages and sclerotin. The significant increase of 
      MFI and decreased expression percentage of monocyte CD147 might be the results of 
      increased disease activity of RA and monocyte migration to the synovial membrane 
      tissue.
FAU - Wang, Zhi-Zhong
AU  - Wang ZZ
AD  - Department of Integrative Medicine, Southwest Hospital, Third Military Medical 
      University, Chongqing 400038, China.
FAU - Wang, Yong
AU  - Wang Y
FAU - Li, Jun-Mei
AU  - Li JM
FAU - Mou, Fang-Xiang
AU  - Mou FX
FAU - Wu, Hong
AU  - Wu H
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (BSG protein, human)
RN  - 0 (TIMP1 protein, human)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 136894-56-9 (Basigin)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*blood/diagnosis
MH  - Basigin/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Medicine, Chinese Traditional
MH  - Middle Aged
MH  - Monocytes/*metabolism
MH  - Tissue Inhibitor of Metalloproteinase-1/*blood
EDAT- 2013/08/29 06:00
MHDA- 2014/09/26 06:00
CRDT- 2013/08/29 06:00
PHST- 2013/08/29 06:00 [entrez]
PHST- 2013/08/29 06:00 [pubmed]
PHST- 2014/09/26 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Jun;33(6):770-3.