PMID- 23980639
OWN - NLM
STAT- MEDLINE
DCOM- 20141031
LR  - 20231213
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 29
IP  - 3
DP  - 2014 Mar
TI  - HLA-DP and gamma-interferon receptor-2 gene variants and their association with viral 
      hepatitis activity in chronic hepatitis B infection.
PG  - 533-9
LID - 10.1111/jgh.12378 [doi]
AB  - BACKGROUND AND AIM: Studies show that polymorphisms in human leukocyte antigen 
      (HLA)-DP loci and certain gamma-interferon (IFN-gamma) signaling pathway genes are 
      related to persistence of hepatitis B virus (HBV) infection and viral load in 
      chronic HBV (CHB) infection respectively. Our study aims to determine whether 
      single-nucleotide polymorphisms (SNPs) linked to HLA-DP loci and IFN-gamma signaling 
      pathway are associated with HBV activities. METHODS: We compared the SNPs in the 
      HLA-DPA1 gene (rs3077) and the IFN-gamma receptor-2 gene (rs2284553 and rs9808753) of 
      100 treatment-naive hepatitis B e antigen (HBeAg)-negative CHB patients with 
      undetectable HBV DNA with 100 age- and sex-matched controls with HBV 
      DNA > 2000 IU/mL. RESULTS: The median age of the study group was 47.9 years, and 
      61% were male patients. The distribution of the three polymorphisms was in 
      Hardy-Weinberg equilibrium. Both rs3077 and rs2284553 polymorphisms were not 
      associated with HBV viral load in terms of allelic frequency, genotypic 
      frequency, dominant/recessive gene action. rs9808753 (G allele) was associated 
      with a reduced chance of "undetectable HBV DNA" for patients below the age of 50 
      years in allelic frequency analysis (odds ratio 0.562; 95% confidence interval, 
      0.326-0.967; P value = 0.037). IFN-gamma receptor-2 gene haplotype block 
      (rs2284553/rs9808753) was not associated with HBV viral activity. CONCLUSION: 
      There was no significant association between HLA-DP polymorphism (rs3077) and 
      IFN-gamma receptor-2 gene polymorphism (rs2284553) with viral activity in 
      HBeAg-negative CHB patients. Further studies are required to confirm the 
      association between IFN-gamma receptor-2 gene polymorphism (rs9808753) and reduced 
      chance of having "undetectable HBV DNA" in young CHB patients.
CI  - (c) 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing 
      Asia Pty Ltd.
FAU - Lam, Yuk-Fai
AU  - Lam YF
AD  - Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong 
      Kong, China.
FAU - Wong, Danny Ka-Ho
AU  - Wong DK
FAU - Seto, Wai-Kay
AU  - Seto WK
FAU - To, Kelvin Kai-Wang
AU  - To KK
FAU - Hung, Ivan Fan-Ngai
AU  - Hung IF
FAU - Fung, James
AU  - Fung J
FAU - Lai, Ching-Lung
AU  - Lai CL
FAU - Yuen, Man-Fung
AU  - Yuen MF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (DNA, Viral)
RN  - 0 (HLA-DP alpha-Chains)
RN  - 0 (HLA-DPA1 antigen)
RN  - 0 (Hepatitis B e Antigens)
RN  - 0 (Receptors, Interferon)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - DNA, Viral
MH  - Female
MH  - Gene Frequency
MH  - HLA-DP alpha-Chains/*genetics
MH  - Hepatitis B e Antigens
MH  - Hepatitis B virus/genetics
MH  - Hepatitis B, Chronic/*genetics/*virology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Interferon/*genetics
MH  - Signal Transduction/genetics
MH  - Viral Load/*genetics
MH  - Young Adult
MH  - Interferon gamma Receptor
OTO - NOTNLM
OT  - HLA-DP
OT  - IFN-gamma pathway
OT  - chronic hepatitis B
EDAT- 2013/08/29 06:00
MHDA- 2014/11/02 06:00
CRDT- 2013/08/29 06:00
PHST- 2013/08/09 00:00 [accepted]
PHST- 2013/08/29 06:00 [entrez]
PHST- 2013/08/29 06:00 [pubmed]
PHST- 2014/11/02 06:00 [medline]
AID - 10.1111/jgh.12378 [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2014 Mar;29(3):533-9. doi: 10.1111/jgh.12378.