PMID- 23982226
OWN - NLM
STAT- MEDLINE
DCOM- 20140317
LR  - 20210102
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 8
IP  - 4
DP  - 2013 Oct
TI  - CpG oligodeoxynucleotide induces bone marrow precursor cells into myeloid-derived 
      suppressor cells.
PG  - 1149-54
LID - 10.3892/mmr.2013.1655 [doi]
AB  - Dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) perform a 
      number of functions in different immunological settings. In standard in vitro 
      experiments, DCs are produced from mouse bone marrow (BM) cells in the presence 
      of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4. Our 
      previous study demonstrated that BM precursor cells could differentiate into 
      MDSCs when co-cultured with poly (I:C). In the present study, BM precursor cells 
      cultured in GM-CSF and IL-4 were treated with CpG oligodeoxynucleotide (CpG ODN). 
      We observed that Gr1+CD11b+ cells exhibiting MDSC functions accumulated in the 
      co-culture system. A similar phenomenon was also observed in Listeria 
      monocytogenes-infected mice. In conclusion, we demonstrated that prolonged CpG 
      ODN stimulation could inhibit the development of DCs and induce the 
      differentiation of BM precursor cells into MDSCs.
FAU - Chen, Jie
AU  - Chen J
AD  - Department of Immunology, National Key Laboratory of Medical Immunology and 
      Institute of Immunology, Second Military Medical University, Shanghai 200433, 
      P.R. China.
FAU - Deng, Chengyu
AU  - Deng C
FAU - Shi, Qingmin
AU  - Shi Q
FAU - Jiang, Jun
AU  - Jiang J
FAU - Zhang, Yongbo
AU  - Zhang Y
FAU - Shan, Wei
AU  - Shan W
FAU - Sun, Weimin
AU  - Sun W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130827
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (CpG ODN 2216)
RN  - 0 (Cytokines)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (Toll-Like Receptor 9)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/*drug effects
MH  - Cell Proliferation
MH  - Coculture Techniques
MH  - Cytokines/metabolism
MH  - Dendritic Cells/metabolism
MH  - Female
MH  - Listeria monocytogenes/immunology
MH  - Listeriosis/immunology/metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myeloid Cells/*metabolism
MH  - Myeloid Progenitor Cells/drug effects/*physiology
MH  - Oligodeoxyribonucleotides/*pharmacology
MH  - Phagocytosis
MH  - Phenotype
MH  - T-Lymphocytes/immunology
MH  - Toll-Like Receptor 9/agonists
EDAT- 2013/08/29 06:00
MHDA- 2014/03/19 06:00
CRDT- 2013/08/29 06:00
PHST- 2012/12/29 00:00 [received]
PHST- 2013/07/17 00:00 [accepted]
PHST- 2013/08/29 06:00 [entrez]
PHST- 2013/08/29 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
AID - 10.3892/mmr.2013.1655 [doi]
PST - ppublish
SO  - Mol Med Rep. 2013 Oct;8(4):1149-54. doi: 10.3892/mmr.2013.1655. Epub 2013 Aug 27.