PMID- 23982767
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20211021
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
VI  - 46
IP  - 2
DP  - 2014 Feb
TI  - Urinary brain-derived neurotrophic factor: a potential biomarker for objective 
      diagnosis of overactive bladder.
PG  - 341-7
LID - 10.1007/s11255-013-0540-x [doi]
AB  - PURPOSE: To investigate the diagnostic performance of urinary brain-derived 
      neurotrophic factor (BDNF) and nerve growth factor (NGF) as potential biomarkers 
      for overactive bladder (OAB). METHODS: Ninety women diagnosed with OAB and 45 
      normal controls without OAB were enrolled. Urine samples were collected from all 
      subjects. Urinary BDNF and NGF levels were measured using enzyme-linked 
      immunosorbent assays. Results normalized by urinary creatinine (Cr) levels were 
      compared between OAB groups and controls. Symptom severity was assessed using 
      overactive bladder symptom score. RESULTS: Urinary BDNF and NGF levels were 
      elevated in OAB groups but not in controls. Mean (SD) baseline BDNF and NGF 
      levels normalized by Cr levels were significantly higher in OAB subjects than in 
      controls (20.609 +/- 23.932 vs. 1.779 +/- 0.729, p < 0.01) and (0.258 +/- 0.264 vs. 
      0.081 +/- 0.028, p < 0.01), respectively. Urinary BDNF/Cr levels were 80-fold 
      higher than NGF/Cr levels in OAB subjects. Receiver operating characteristic 
      curves for assessing urinary BDNF/Cr levels in OAB groups showed sensitivity and 
      specificity of 93.33 and 88.89 %, respectively. Urinary BDNF levels were 
      associated with OAB symptom severity. CONCLUSIONS: Urinary BDNF/Cr levels are 
      elevated in women with OAB and are significantly associated with symptom 
      severity. No elevation of BDNF is found in women without OAB. BDNF analysis has 
      better sensitivity than NGF in detecting OAB in subjects without other lower 
      urinary tract disorders. Results of the present study suggest a potential role 
      for BDNF as an objective biomarker for OAB diagnosis.
FAU - Wang, Long-Wang
AU  - Wang LW
AD  - Department of Urology, The Second Affiliated Hospital to Nanchang University, 
      Nanchang, 330006, People's Republic of China.
FAU - Han, Xiao-Min
AU  - Han XM
FAU - Chen, Chao-Hui
AU  - Chen CH
FAU - Ma, Yan
AU  - Ma Y
FAU - Hai, Bo
AU  - Hai B
LA  - eng
PT  - Journal Article
DEP - 20130828
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
CIN - Int Urol Nephrol. 2015 Feb;47(2):317-8. PMID: 25425438
CIN - Int Urol Nephrol. 2015 Feb;47(2):319. PMID: 25532476
MH  - Adult
MH  - Biomarkers/urine
MH  - Brain-Derived Neurotrophic Factor/*urine
MH  - Case-Control Studies
MH  - Creatinine/urine
MH  - Female
MH  - Humans
MH  - Nerve Growth Factor/*urine
MH  - ROC Curve
MH  - Severity of Illness Index
MH  - Urinary Bladder, Overactive/*diagnosis
EDAT- 2013/08/29 06:00
MHDA- 2014/11/13 06:00
CRDT- 2013/08/29 06:00
PHST- 2013/06/18 00:00 [received]
PHST- 2013/08/14 00:00 [accepted]
PHST- 2013/08/29 06:00 [entrez]
PHST- 2013/08/29 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
AID - 10.1007/s11255-013-0540-x [doi]
PST - ppublish
SO  - Int Urol Nephrol. 2014 Feb;46(2):341-7. doi: 10.1007/s11255-013-0540-x. Epub 2013 
      Aug 28.