PMID- 23983163
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20220321
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 28
IP  - 9
DP  - 2013 Sep
TI  - Glucose and lipid homeostasis in adult rat is impaired by early-life exposure to 
      perfluorooctane sulfonate.
PG  - 532-42
LID - 10.1002/tox.20747 [doi]
AB  - Perfluorooctane sulfonate (PFOS), which belongs to the degradation product of 
      many perfluorinated compounds, is on the list of persistent organic pollutants 
      (POPs) and is currently detected in both wildlife and humans. The consequence of 
      gestational and lactational exposure to PFOS on prediabetes effect in offspring 
      was investigated in rats in the present study. Maternal rats were treated with 
      vehicle, 0.5 mg/kg/day or 1.5 mg/kg/day PFOS respectively from gestation day 0 to 
      postnatal day 21. The glucose and lipid metabolism effects were investigated on 
      the offspring in adulthood. The gestational and lactational exposure to PFOS led 
      to low body weight from birth to weaning, and evoked signs of a prediabetic 
      state, with elevated fasting serum insulin and leptin level, impaired glucose 
      tolerance, though the fasting serum glucose and glycosylated serum protein level 
      were normal. Abnormal lipid homeostasis was also observed by the phenomenon of 
      hepatic steatosis and increased gonadal fat pad weight. However, the circulating 
      serum level of fasting triglyceride and cholesterol level were no different from 
      controls. Our results suggested that developmental exposure to PFOS may 
      contribute to glucose and lipid metabolic disorder in adulthood.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc., a Wiley company.
FAU - Lv, Ziquan
AU  - Lv Z
AD  - Ministry of Education Key Laboratory of Environment and Health, School of Public 
      Health, Tongji Medical College, Huazhong University of Science and Technology, 
      Wuhan 430030, China.
FAU - Li, Gengqi
AU  - Li G
FAU - Li, Yuanyuan
AU  - Li Y
FAU - Ying, Chenjiang
AU  - Ying C
FAU - Chen, Jun
AU  - Chen J
FAU - Chen, Tian
AU  - Chen T
FAU - Wei, Jie
AU  - Wei J
FAU - Lin, Yi
AU  - Lin Y
FAU - Jiang, Ying
AU  - Jiang Y
FAU - Wang, Youjie
AU  - Wang Y
FAU - Shu, Baihuai
AU  - Shu B
FAU - Xu, Bing
AU  - Xu B
FAU - Xu, Shunqing
AU  - Xu S
LA  - eng
PT  - Journal Article
DEP - 20110824
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 0 (Triglycerides)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adipose Tissue/physiopathology
MH  - Alkanesulfonic Acids/*toxicity
MH  - Animals
MH  - Animals, Newborn
MH  - Environmental Pollutants/*toxicity
MH  - Fatty Liver/pathology
MH  - Female
MH  - Fluorocarbons/*toxicity
MH  - Glucose/*metabolism
MH  - Glucose Intolerance
MH  - Homeostasis
MH  - Insulin/blood
MH  - *Lactation
MH  - Leptin/blood
MH  - Lipid Metabolism/*drug effects
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Prediabetic State/blood
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*metabolism/physiopathology
MH  - Rats
MH  - Rats, Wistar
MH  - Triglycerides/blood
MH  - Weight Gain
OTO - NOTNLM
OT  - developmental exposure
OT  - diabetes
OT  - energy metabolism
OT  - low birth weight
OT  - perfluorooctane sulfate
EDAT- 2013/08/29 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/08/29 06:00
PHST- 2011/02/17 00:00 [received]
PHST- 2011/05/05 00:00 [revised]
PHST- 2011/05/22 00:00 [accepted]
PHST- 2013/08/29 06:00 [entrez]
PHST- 2013/08/29 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1002/tox.20747 [doi]
PST - ppublish
SO  - Environ Toxicol. 2013 Sep;28(9):532-42. doi: 10.1002/tox.20747. Epub 2011 Aug 24.