PMID- 23983226
OWN - NLM
STAT- MEDLINE
DCOM- 20140326
LR  - 20140131
IS  - 1938-3673 (Electronic)
IS  - 0741-5400 (Linking)
VI  - 95
IP  - 2
DP  - 2014 Feb
TI  - Prostaglandin E2 imprints a long-lasting effect on dendritic cell progenitors in 
      the bone marrow.
PG  - 225-32
LID - 10.1189/jlb.0513294 [doi]
AB  - Dendritic cells (DCs) that differentiate in vitro from the bone marrow (BM) of 
      mice with prostaglandin E2 (PGE2)-associated inflammation of the skin, airways, 
      or peritoneal cavity poorly initiate immune responses. To remove in vitro 
      differentiation and allow BM-derived DCs to seed the periphery under steady-state 
      conditions, as well as study the molecule proposed responsible, chimeric mice 
      were engrafted for >16 wk with BM cells from mice exposed to PGE2. Serial 
      PGE2-chimeric mice were established with BM cells from the primary chimeric mice. 
      Immune responses in the airways and skin of the PGE2-chimeric mice and serial 
      PGE2-chimeric mice were significantly attenuated. After inflammatory challenges 
      by intranasal LPS, topical fluorescein isothiocyanate, and intraperitoneal alum, 
      DCs, macrophages, and neutrophils trafficked poorly in PGE2-chimeric mice and 
      serial PGE2-chimeric mice. Injection of BM-differentiated DCs from nonchimeric 
      mice restored the reduced immune responses of PGE2-chimeric mice. DCs from BM of 
      16-wk-engrafted PGE2-chimeric and serial PGE2-chimeric mice resembled cells 
      differentiated from BM exposed to PGE2 for only 3 d, demonstrating the 
      long-lasting effect of PGE2 on DC progenitors. PGE2 attenuates systemic immune 
      responses by modulating myeloid cell progenitors in the BM such that BM-derived, 
      terminally differentiated myeloid cells have poor trafficking ability to sites of 
      need.
FAU - Scott, Naomi M
AU  - Scott NM
AD  - 1.University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia. 
      prueh@ichr.uwa.edu.au.
FAU - Ng, Royce L X
AU  - Ng RL
FAU - Gorman, Shelley
AU  - Gorman S
FAU - Norval, Mary
AU  - Norval M
FAU - Waithman, Jason
AU  - Waithman J
FAU - Hart, Prue H
AU  - Hart PH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130827
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Lipopolysaccharides)
RN  - I223NX31W9 (Fluorescein-5-isothiocyanate)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
CIN - J Leukoc Biol. 2014 Feb;95(2):201-4. PMID: 24482486
MH  - Administration, Intranasal
MH  - Administration, Topical
MH  - Animals
MH  - Bone Marrow Cells/*cytology/drug effects/radiation effects
MH  - Bone Marrow Transplantation
MH  - Cell Differentiation/drug effects/radiation effects
MH  - Chimera/immunology
MH  - Dendritic Cells/*cytology/drug effects/*immunology/radiation effects
MH  - Dinoprostone/*pharmacology
MH  - Female
MH  - Fluorescein-5-isothiocyanate/pharmacology
MH  - Gamma Rays
MH  - Hypersensitivity/immunology/pathology
MH  - Immunity/drug effects/radiation effects
MH  - Inflammation/pathology
MH  - Lipopolysaccharides/pharmacology
MH  - Lymph Nodes/drug effects/pathology/radiation effects
MH  - Macrophages/drug effects/radiation effects
MH  - Mice
MH  - Neutrophils/drug effects/radiation effects
MH  - Stem Cells/*cytology/drug effects/*immunology/radiation effects
MH  - Time Factors
OTO - NOTNLM
OT  - Immunosuppression
OT  - UV irradiation
OT  - chimeric mice
OT  - hemopoietic stem cells
OT  - inflammation
OT  - macrophages
EDAT- 2013/08/29 06:00
MHDA- 2014/03/29 06:00
CRDT- 2013/08/29 06:00
PHST- 2013/08/29 06:00 [entrez]
PHST- 2013/08/29 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - jlb.0513294 [pii]
AID - 10.1189/jlb.0513294 [doi]
PST - ppublish
SO  - J Leukoc Biol. 2014 Feb;95(2):225-32. doi: 10.1189/jlb.0513294. Epub 2013 Aug 27.