PMID- 23983885
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130828
LR  - 20211021
IS  - 1941-8744 (Print)
IS  - 1941-8752 (Electronic)
IS  - 1941-8744 (Linking)
VI  - 3
IP  - 1
DP  - 2013 Jan
TI  - Neurological complications of transplantation: part I: hematopoietic cell 
      transplantation.
PG  - 24-38
LID - 10.1177/1941874412455338 [doi]
AB  - Hematopoietic cell transplantation (HCT) is the preferred treatment for an 
      expanding range of neoplastic and nonmalignant conditions. Increasing numbers of 
      solid organ transplantations (SOTs) add an additional population of 
      immunosuppressed patients with multiple potential neurological problems. While 
      the spectrum of neurological complications varies with conditioning procedure and 
      hematopoietic cell or solid organ source, major neurological complications occur 
      with all transplantation procedures. This 2 part review emphasizes a practical 
      consultative approach to central and peripheral nervous system problems related 
      to HCT or SOT with clinical and neuroimaging examples from the authors' 
      institutional experience with the following conditions: the diversity of 
      manifestations of common infections such as varicella zoster virus, Aspergillus, 
      and progressive multifocal leukoencephalopathy (PML), drug therapy-related 
      complications, stroke mechanisms, the spectrum of graft versus host disease 
      (GVHD), and neurologically important syndromes of immune reconstitution 
      inflammatory syndrome (IRIS), posterior reversible encephalopathy syndrome 
      (PRES), and posttransplantation lymphoproliferative disorder (PTLD). These 
      complications preferentially occur at specific intervals after HCT and SOT, and 
      neurological consultants must recognize an extensive spectrum of syndromes in 
      order to effect timely diagnosis and expedite appropriate treatment.
FAU - Pruitt, Amy A
AU  - Pruitt AA
AD  - Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Graus, Francesc
AU  - Graus F
FAU - Rosenfeld, Myrna R
AU  - Rosenfeld MR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurohospitalist
JT  - The Neurohospitalist
JID - 101558199
PMC - PMC3726122
OTO - NOTNLM
OT  - Aspergillus
OT  - graft versus host disease
OT  - hematopoietic cell transplantation
OT  - immune reconstitution inflammatory syndrome
OT  - organ transplantation
OT  - posterior reversible encephalopathy syndrome
OT  - posttransplantation lymphoproliferative disorder
OT  - progressive multifocal leukoencephalopathy
OT  - varicella zoster virus
COIS- Declaration of Conflicting Interests: The authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2013/08/29 06:00
MHDA- 2013/08/29 06:01
PMCR- 2013/01/01
CRDT- 2013/08/29 06:00
PHST- 2013/08/29 06:00 [entrez]
PHST- 2013/08/29 06:00 [pubmed]
PHST- 2013/08/29 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.1177_1941874412455338 [pii]
AID - 10.1177/1941874412455338 [doi]
PST - ppublish
SO  - Neurohospitalist. 2013 Jan;3(1):24-38. doi: 10.1177/1941874412455338.