PMID- 23983958 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20130828 LR - 20211021 IS - 2045-1253 (Print) IS - 2045-1261 (Electronic) IS - 2045-1253 (Linking) VI - 2 IP - 2 DP - 2012 Apr TI - Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features. PG - 65-74 LID - 10.1177/2045125312436572 [doi] AB - OBJECTIVE: Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and leptin have been hypothesized to be involved in the neurobiology of depression. The aim of this study was to investigate BDNF, VEGF and leptin levels in patients with severe melancholic depression. METHODS: A total of 40 drug-free patients with major depressive disorder (MDD) with melancholic features and 40 healthy controls were included in the study. Demographic information, psychiatric evaluation and physical examination were documented for both groups. Serum BDNF, VEGF levels were determined by enzyme-linked immunosorbent assay and leptin with radioimmunoassay methods. The Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were applied to the patients. RESULTS: There were no significant differences in serum BDNF, VEGF and leptin levels between the patient and control groups. There was a negative correlation between BDNF levels and the number of depressive episodes. It was noted that VEGF levels decreased with increasing severity of depression. CONCLUSIONS: These findings suggest that BDNF levels might be associated with the recurrence of depression and VEGF levels might be a determinant of the severity of depression. FAU - Kotan, Zeynep AU - Kotan Z FAU - Sarandol, Emre AU - Sarandol E FAU - Kirhan, Emine AU - Kirhan E FAU - Ozkaya, Guven AU - Ozkaya G FAU - Kirli, Selccuk AU - Kirli S LA - eng PT - Journal Article PL - England TA - Ther Adv Psychopharmacol JT - Therapeutic advances in psychopharmacology JID - 101555693 PMC - PMC3736932 OTO - NOTNLM OT - brain-derived neurotrophic factor OT - depression OT - leptin OT - vascular endothelial growth factor COIS- The authors declare no conflicts of interest in preparing this article. EDAT- 2012/04/01 00:00 MHDA- 2012/04/01 00:01 PMCR- 2012/04/01 CRDT- 2013/08/29 06:00 PHST- 2013/08/29 06:00 [entrez] PHST- 2012/04/01 00:00 [pubmed] PHST- 2012/04/01 00:01 [medline] PHST- 2012/04/01 00:00 [pmc-release] AID - 10.1177_2045125312436572 [pii] AID - 10.1177/2045125312436572 [doi] PST - ppublish SO - Ther Adv Psychopharmacol. 2012 Apr;2(2):65-74. doi: 10.1177/2045125312436572.