PMID- 23984162
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130828
LR  - 20211021
IS  - 2090-6889 (Print)
IS  - 2090-6897 (Electronic)
IS  - 2090-6897 (Linking)
VI  - 2013
DP  - 2013
TI  - A case of subacute cutaneous lupus erythematosus in a patient with mixed 
      connective tissue disease: successful treatment with plasmapheresis and 
      rituximab.
PG  - 857694
LID - 10.1155/2013/857694 [doi]
LID - 857694
AB  - A 30-year-old woman affected by Mixed Connective Tissue Disease with scleroderma 
      spectrum developed a facial eruption, a clinical and histological characteristic 
      of subacute cutaneous lupus erythematosus (SCLE). Speckled anti-nuclear 
      antibodies, high-titer anti-ribonucleoprotein1, anti-Sm, anti-Cardiolipin (aCL) 
      IgG/IgM, and anti-Ro/SSA antibodies were positive. SCLE was resistant to 
      Azathioprine, Hydroxychloroquine, and Methotrexate while Mycophenolate Mofetil 
      was suspended due to side effects. Subsequently, the patient was treated with 
      three cycles of therapeutic plasma exchange (TPE) followed, one month after the 
      last TPE, by the anti-CD20 antibody Rituximab (RTX) (375 mg/m(2) weekly for 4 
      weeks). Eight and 16 months later the patient received other two TPE and RTX 
      cycles, respectively. This therapeutic approach has allowed to obtain a complete 
      skin healing persistent even after 8-month follow-up. Moreover, mitigation of 
      Raynaud's phenomenon, resolution of alopecia, and a decline of aCL IgG/IgM and 
      anti-Ro/SSA antibodies were observed.
FAU - Fanto, M
AU  - Fanto M
AD  - Department of Allergy, Clinical Immunology and Rheumatology, S. Andrea Hospital, 
      Sapienza University of Rome, Italy.
FAU - Salemi, S
AU  - Salemi S
FAU - Socciarelli, F
AU  - Socciarelli F
FAU - Bartolazzi, A
AU  - Bartolazzi A
FAU - Natale, G A
AU  - Natale GA
FAU - Casorelli, I
AU  - Casorelli I
FAU - Pavan, A
AU  - Pavan A
FAU - Vaglio, S
AU  - Vaglio S
FAU - Di Rosa, R
AU  - Di Rosa R
FAU - D'Amelio, R
AU  - D'Amelio R
LA  - eng
PT  - Journal Article
DEP - 20130728
PL  - United States
TA  - Case Rep Rheumatol
JT  - Case reports in rheumatology
JID - 101585353
PMC - PMC3745888
EDAT- 2013/08/29 06:00
MHDA- 2013/08/29 06:01
PMCR- 2013/07/28
CRDT- 2013/08/29 06:00
PHST- 2013/06/04 00:00 [received]
PHST- 2013/06/26 00:00 [accepted]
PHST- 2013/08/29 06:00 [entrez]
PHST- 2013/08/29 06:00 [pubmed]
PHST- 2013/08/29 06:01 [medline]
PHST- 2013/07/28 00:00 [pmc-release]
AID - 10.1155/2013/857694 [doi]
PST - ppublish
SO  - Case Rep Rheumatol. 2013;2013:857694. doi: 10.1155/2013/857694. Epub 2013 Jul 28.