PMID- 23984427
OWN - NLM
STAT- MEDLINE
DCOM- 20140318
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2013
DP  - 2013
TI  - Growth factors serum levels in coronary artery disease patients scheduled for 
      bypass surgery: perioperative dynamics and comparisons with healthy volunteers.
PG  - 985404
LID - 10.1155/2013/985404 [doi]
LID - 985404
AB  - BACKGROUND: Vascular endothelial growth factors are important mediators for 
      neovascularization of chronically ischemic adult heart, but their elevated values 
      have also been connected with acute ischemia. Coronary artery bypass grafting 
      (CABG) is associated with activation of inflammatory processes. We aimed to 
      clarify whether the latter is also accompanied with acute changes in 
      concentrations of vascular growth factors. METHODS: Concentrations of growth 
      factors VEGF and EGF, monocyte chemoattractant protein-1 (MCP-1), and a set of 
      cytokines of 39 patients with stable coronary artery disease (CAD) were evaluated 
      before and after CABG. Preoperative values were compared with data of healthy 
      volunteers. RESULTS: In comparison with CAD patients, healthy controls had 
      significantly higher values of VEGF (15.5 (10.05-35.3) and 119.4 (55.7-136.9) 
      pg/mL, resp.), EGF (1.70 (1.14-3.18) and 37.3 (27.1-51.9) pg/mL, resp.), and 
      MCP-1 (111.6 (81.75-171.9) and 156.9 (134.7-241.3) pg/mL, resp.). MCP-1, but not 
      others, demonstrated a significant rise throughout the postoperative period. 
      Proinflammatory interleukin-6 was significantly higher and anti-inflammatory IL-4 
      and IL-10 lower in patients with CAD. CONCLUSIONS: Patients with stable CAD have 
      lower serum levels of growth factors than healthy volunteers. MCP-1, but not VEGF 
      and EGF, becomes elevated immediately after CABG. Inflammatory status of CAD 
      patients was drifted towards proinflammatory state.
FAU - Karu, Inga
AU  - Karu I
AD  - North Estonia Medical Centre, Clinic of Anaesthesiology, Sutiste 19, 13419 
      Tallinn, Estonia. inga.karu@regionaalhaigla.ee
FAU - Starkopf, Joel
AU  - Starkopf J
FAU - Zilmer, Kersti
AU  - Zilmer K
FAU - Zilmer, Mihkel
AU  - Zilmer M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130729
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/blood
MH  - *Coronary Artery Bypass
MH  - Coronary Artery Disease/*blood/*surgery
MH  - Cytokines/blood
MH  - Epidermal Growth Factor/blood
MH  - Female
MH  - *Healthy Volunteers
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Male
MH  - Middle Aged
MH  - *Perioperative Care
MH  - Vascular Endothelial Growth Factor A/blood
PMC - PMC3745908
EDAT- 2013/08/29 06:00
MHDA- 2014/03/19 06:00
PMCR- 2013/07/29
CRDT- 2013/08/29 06:00
PHST- 2013/04/21 00:00 [received]
PHST- 2013/07/09 00:00 [accepted]
PHST- 2013/08/29 06:00 [entrez]
PHST- 2013/08/29 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
PHST- 2013/07/29 00:00 [pmc-release]
AID - 10.1155/2013/985404 [doi]
PST - ppublish
SO  - Biomed Res Int. 2013;2013:985404. doi: 10.1155/2013/985404. Epub 2013 Jul 29.