PMID- 23984511
OWN - NLM
STAT- MEDLINE
DCOM- 20160125
LR  - 20181202
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 48
IP  - 6
DP  - 2013 Jun
TI  - [The associations between idiosyncratic adverse drug reactions and HLA alleles 
      and their underlying mechanism].
PG  - 799-808
AB  - With the advent of Twenty-First century, more and more genome-wide association 
      studies (GWAS) showed that idiosyncratic adverse drug reactions (ADRs) were 
      closely related with human leukocyte antigen (HLA) alleles, such as the 
      associations of abacavir-HLA-B*5701, allopurinol-HLA-B*5801, and 
      carbamazepine-HLA-B*1502, etc. To explore the mechanisms of these idiosyncratic 
      drug reactions, hapten hypothesis, danger signal hypothesis, pharmacological 
      interaction (P-I) concept and autoimmune mechanism are proposed. In this paper, 
      recent GWAS studies on the HLA-mediated adverse drug reactions and underlying 
      mechanism are reviewed in detail.
FAU - Wang, Qing
AU  - Wang Q
AD  - College of Bioengineering, Chongqing University, Chongqing 400044, China.
FAU - Mei, Hu
AU  - Mei H
FAU - Zhang, Ya-Lan
AU  - Zhang YL
FAU - Pan, Xian-Chao
AU  - Pan XC
FAU - Tan, Wen
AU  - Tan W
FAU - Chao, Li
AU  - Chao L
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Anticonvulsants)
RN  - 0 (Dideoxynucleosides)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*15:02 antigen)
RN  - 0 (HLA-B*57:01 antigen)
RN  - 0 (HLA-B*58:01 antigen)
RN  - 0 (HLA-B15 Antigen)
RN  - 33CM23913M (Carbamazepine)
RN  - 63CZ7GJN5I (Allopurinol)
RN  - WR2TIP26VS (abacavir)
SB  - IM
MH  - Alleles
MH  - Allopurinol/adverse effects
MH  - Anti-HIV Agents/adverse effects
MH  - Anticonvulsants/adverse effects
MH  - Carbamazepine/adverse effects
MH  - Dideoxynucleosides/adverse effects
MH  - Drug Hypersensitivity Syndrome/etiology/immunology
MH  - Drug-Related Side Effects and Adverse Reactions/*genetics/immunology
MH  - Enzyme Inhibitors/adverse effects
MH  - *Genome-Wide Association Study
MH  - HLA Antigens/*genetics
MH  - HLA-B Antigens/immunology
MH  - HLA-B15 Antigen/immunology
MH  - Humans
MH  - Stevens-Johnson Syndrome/etiology/immunology
EDAT- 2013/08/30 06:00
MHDA- 2016/01/26 06:00
CRDT- 2013/08/30 06:00
PHST- 2013/08/30 06:00 [entrez]
PHST- 2013/08/30 06:00 [pubmed]
PHST- 2016/01/26 06:00 [medline]
PST - ppublish
SO  - Yao Xue Xue Bao. 2013 Jun;48(6):799-808.